Multiclonal epidemic of Klebsiella pneumoniae isolates producing DHA-1 in a Spanish hospital

K. Diestra, E. Miró, C. Martí, D. Navarro, J. Cuquet, P. Coll, F. Navarro

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Between June 2007 and January 2008, 26 Klebsiella pneumoniae isolates carrying blaDHA-1 on an IncL/M plasmid were obtained from clinical samples at Granollers Hospital, Barcelona, Spain. Three of the isolates also carried a blaCTX-M-15 gene. The 26 isolates showed 11 pulsed-field gel electrophoresis (PFGE) patterns. Multilocus sequence typing showed that PFGE patterns A, B and C belonged to sequence type (ST)17, D to ST13, E to ST427, F and G to ST416, H to ST37, I to ST440, J to ST326, and K to ST428. Results demonstrated the effectiveness of the infection control programme in place at the centre. This study reports the first characterization of STs for blaDHA-1-producing K. pneumoniae isolates. © 2010 The Authors. Clinical Microbiology and Infection © 2010 European Society of Clinical Microbiology and Infectious Diseases.
Original languageEnglish
Pages (from-to)1032-1036
JournalClinical Microbiology and Infection
Issue number7
Publication statusPublished - 1 Jan 2011


  • AmpC
  • Epidemiology
  • ESBL
  • Multilocus sequence typing
  • Resistance mechanisms


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