mtDNA nt13708A variant increases the risk of multiple sclerosis

Xinhua Yu, Dirk Koczan, Anna Maija Sulonen, Denis A. Akkad, Antje Kroner, Manuel Comabella, Gianna Costa, Daniela Corongiu, Robert Goertsches, Montserrat Camina-Tato, Hans Juergen Thiesen, Harald I. Nyland, Sverre J. Mørk, Xavier Montalban, Peter Rieckmann, Maria G. Marrosu, Kjell Morten Myhr, Joerg T. Epplen, Janna Saarela, Saleh M. Ibrahim

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53 Citations (Scopus)

Abstract

Background: Mitochondrial DNA (mtDNA) polymorphism is a possible factor contributing to the maternal parent-of-origin effect in multiple sclerosis (MS) susceptibility. Methods and Findings: In order to investigate the role of mtDNA variations in MS, we investigated six European MS case control cohorts comprising >5,000 individuals. Three well matched cohorts were genotyped with seven common, potentially functional mtDNA single nucleotide polymorphisms (SNPs). A SNP, nt13708 G/A, was significantly associated with MS susceptibility in all three cohorts. The nt13708A allele was associated with an increased risk of MS (OR = 1.71, 95% CI 1.28-2.26, P = 0.0002). Subsequent sequencing of the mtDNA of 50 individuals revealed that the nt13708 itself, rather than SNPs linked to it, was responsible for the association. However, the association of nt13708 G/A with MS was not significant in MS cohorts which were not well case-control matched, indicating that the significance of association was affected by the population structure of controls. Conclusions: Taken together, our finding identified the nt13708A variant as a susceptibility allele to MS, which could contribute to defining the role of the mitochondrial genome in MS pathogenesis. © 2008 Yu et al.
Original languageEnglish
Article numbere1530
JournalPLoS ONE
Volume3
Issue number2
DOIs
Publication statusPublished - 13 Feb 2008

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