MPTP: Advances from an evergreen neurotoxin

Anna R. Carta*, Augusta Pisanu, Carlos Barcia, M. T. Herrero

*Corresponding author for this work

Research output: Chapter in BookChapterResearchpeer-review


Since its discovery in 1976, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models in rodents and nonhuman primates have continuously renewed to keep up with progresses of Parkinson's disease (PD) research. MPTP is able to reproduce almost all the clinical and neuropathological features of PD when administered to monkeys. In contrast, up to date no rodent model has been able to reproduce all PD features in one. Nevertheless, MPTP is a very versatile neurotoxin that can reproduce different aspects of PD pathology, depending upon the dose and regimen of administration. At the present time, a number of different MPTP models have been developed, allowing researchers to investigate either the classical PD neuropathology and neuroprotective mechanisms or known pathological processes underlining more recently discovered aspects of the disease, such as nonmotor symptoms. In this chapter primate and rodent MPTP models are reviewed, focusing mainly on the contribution that different MPTP protocols can offer to reproduce the multifaceted aspects of the disease.

Original languageEnglish
Title of host publicationHandbook of Neurotoxicity
PublisherSpringer New York
Number of pages26
ISBN (Electronic)9781461458364
ISBN (Print)9781461458357
Publication statusPublished - 1 Jan 2014


  • Model
  • MPTP
  • Parkinson
  • Primate
  • Rodent


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