Mouse siglec-1 mediates trans-infection of surface-bound murine leukemia virus in a sialic acid N-acyl side chain-dependent manner

Elina Erikson, Paul R. Wratil, Martin Frank, Ina Ambiel, Katharina Pahnke, Maria Pino, Parastoo Azadi, Nuria Izquierdo-Useros, Javier Martinez-Picado, Chris Meier, Ronald L. Schnaar, Paul R. Crocker, Werner Reutter, Oliver T. Keppler

    Research output: Contribution to journalArticleResearchpeer-review

    26 Citations (Scopus)

    Abstract

    © 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Background: Human Siglec-1 mediates HIV trans-infection by interaction with virion-associated sialylated gangliosides. Results: Here, Siglec-1 on mouse macrophages mediated trans-infection of surface-bound MLV. This could be inhibited by biosynthetic modification of sialic acids' N-acyl side chain in virus-producer cells. Conclusion: The N-acyl side chain is a critical determinant of Siglec-1-dependent MLV trans-infection. Significance: Glycoengineering allows manipulation of sialic acid-dependent virus/receptor interactions.
    Original languageEnglish
    Pages (from-to)27345-27359
    JournalJournal of Biological Chemistry
    Volume290
    Issue number45
    DOIs
    Publication statusPublished - 6 Nov 2015

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