Mouse Models of Alzheimer's Disease

Gisela Esquerda-Canals, Laia Montoliu-Gaya, Jofre Güell-Bosch, Sandra Villegas

Research output: Contribution to journalReview articleResearchpeer-review

80 Citations (Scopus)

Abstract

© 2017 - IOS Press and the authors. All rights reserved. Alzheimer's disease (AD) is a neurodegenerative disorder that nowadays affects more than 40 million people worldwide and it is predicted to exponentially increase in the coming decades. Because no curative treatment exists, research on the pathophysiology of the disease, as well as the testing of new drugs, are mandatory. For these purposes, animal models constitute a valuable, although perfectible tool. This review takes a tour through several aspects of mouse models of AD, such as the generation of transgenic models, the relevance of the promoter driving the expression of the transgenes, and the concrete transgenes used to simulate AD pathophysiology. Then, transgenic mouse lines harboring mutated human genes at several loci such as APP, PSEN1, APOE ϵ4, and ob (leptin) are reviewed. Therefore, not only the accumulation of the Aβ peptide is emulated but also cholesterol and insulin metabolism. Further novel information about the disease will allow for the development of more accurate animal models, which in turn will undoubtedly be helpful for bringing preclinical research closer to clinical trials in humans.
Original languageEnglish
Pages (from-to)1171-1183
JournalJournal of Alzheimer's Disease
Volume57
Issue number4
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Alzheimer's disease
  • amyloid-β
  • animal models
  • apoE
  • APP
  • ob mutation
  • PS1

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