Mortality trends in an ambulatory multidisciplinary heart failure unit from 2001 to 2018

Giosafat Spitaleri, Josep Lupón, Mar Domingo, Evelyn Santiago-Vacas, Pau Codina, Elisabet Zamora, Germán Cediel, Javier Santesmases, Crisanto Diez-Quevedo, Maria Isabel Troya, Maria Boldo, Salvador Altmir, Nuria Alonso, Beatriz González, Julio Núñez, Antoni Bayes-Genis*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)


To assess mortality trends at 1 and 3 years from 2001 to 2018 in a real-life cohort of HF outpatients from different etiologies with depressed and preserved LVEF. A total of 2368 consecutive patients with HF (mean age 66.4 ± 12.9 years, 71% men, 15.4% with preserved LVEF) admitted to a HF clinic from August 2001 to September 2018 were included in the study. Patients were divided into five quintiles (Q) according to the period of admission. Trends for all-cause and cardiovascular mortality from Q1 to Q5 were assessed by linear regression. Patients with LVEF < 50% had a progressive decrease in the rates of all-cause and cardiovascular death at 1 year (12.1% in Q1 to 6.5% in Q5, p = 0.003; and 8.4% in Q1 to 3.8% in Q5, p = 0.007, respectively) and 3 years (30.5% in Q1 to 17.0% in Q5, p = 0.003; and 23.9% in Q1 to 9.8% in Q5, p = 0.003, respectively). These trends remained significant after adjusting for clinical characteristics and risk. No significant trend in mortality was observed in patients with LVEF ≥ 50%. In a cohort of real-life ambulatory patients with HF, mortality progressively declined in patients with LVEF < 50%, but the same trend was not observed in patients with preserved LVEF.
Original languageAmerican English
Article number732
Pages (from-to)732
Number of pages10
JournalScientific Reports
Issue number1
Publication statusPublished - 12 Jan 2021


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