Mortality study in patients at weaning from mechanical ventilation

© 2019 Elsevier España, S.L.U. y SEMICYUC Objective: To explain mortality in the ICU and in hospital among patients subjected to invasive mechanical ventilation. Design: A prospective, 9-month observational cohort study was carried out. Setting: A Department of Intensive Care Medicine. Patients: Consecutive patients requiring invasive mechanical ventilation were followed-up on until hospital discharge or death. Interventions: None. Interest variables: Date of admission, day of first spontaneous breathing test, length of mechanical ventilation, final extubation date, days in ICU, days in hospital or discharge from ICU, SAPS-3 score, WIND study classification, day of death, hospital discharge. Results: There were 266 patients: 40 in group 0 of the WIND classification (15%; 95% CI 11-20%); 166 in group 1 (62%; 95% CI 56-68%); 38 in group 2 (14%; 95% CI 11-19%); and 22 in group 3 (8%; 95% CI 6-12%. Logistic regression analysis showed group 3 to have the highest hospital mortality (group 3 vs. group 1; odds ratio 4.0; 95% CI 1.5-10.8; P = .007). However, Cox regression analysis showed no significant differences (hazard ratio group 3 vs. group 1, 1.6; 95% CI 0.7-3.4; P = ns). Conclusion: In our study, considering exposure time, the probability of mortality was the same among the 3 different groups of patients with at least one spontaneous breathing test.