Morphological, histological and immunohistochemical study of the area postrema in the dog

Marti Pumarola Batlle, Francisco Fernandez Flores, Maria Oliveira, Jordi Solé

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

© 2017, Japanese Association of Anatomists. Circumventricular organs are specialized brain structures that are located mainly at the midsagittal line, around the third and fourth ventricles, often protruding into the lumen. They are positioned at the interface between the neuroparenchyma and the ventricular system of the brain. These highly vascularized nervous tissue structures differ from the brain parenchyma, as they lack a blood–brain barrier. Circumventricular organs have specialized sensory and secretory functions. It is essential for any pathologist who evaluates brain sections to have a solid knowledge of microscopic neuroanatomy and to recognize these numerous specialized structures within the nervous system as normal and not mistake them for pathological changes. The purpose of this study was to provide, for the first time, a detailed and complete histological description of the healthy canine area postrema and to determine its resemblance to that of other mammalian species. Anatomical dissections with routine histological and immunohistochemical techniques were carried out on ten canine brains. The cellular composition of area postrema proved to be largely comparable to that of other mammal species.
Original languageEnglish
Pages (from-to)188-196
JournalAnatomical Science International
Volume93
Issue number2
DOIs
Publication statusPublished - 1 Mar 2018

Keywords

  • Area postrema
  • Circumventricular organs
  • Dog
  • Immunohistochemistry
  • Morphology

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