TY - JOUR
T1 - Morphological, histological and immunohistochemical study of the area postrema in the dog
AU - Oliveira, Maria
AU - Fernández, Francisco
AU - Solé, Jordi
AU - Pumarola, Martí
N1 - Publisher Copyright:
© 2017, Japanese Association of Anatomists.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - © 2017, Japanese Association of Anatomists. Circumventricular organs are specialized brain structures that are located mainly at the midsagittal line, around the third and fourth ventricles, often protruding into the lumen. They are positioned at the interface between the neuroparenchyma and the ventricular system of the brain. These highly vascularized nervous tissue structures differ from the brain parenchyma, as they lack a blood–brain barrier. Circumventricular organs have specialized sensory and secretory functions. It is essential for any pathologist who evaluates brain sections to have a solid knowledge of microscopic neuroanatomy and to recognize these numerous specialized structures within the nervous system as normal and not mistake them for pathological changes. The purpose of this study was to provide, for the first time, a detailed and complete histological description of the healthy canine area postrema and to determine its resemblance to that of other mammalian species. Anatomical dissections with routine histological and immunohistochemical techniques were carried out on ten canine brains. The cellular composition of area postrema proved to be largely comparable to that of other mammal species.
AB - © 2017, Japanese Association of Anatomists. Circumventricular organs are specialized brain structures that are located mainly at the midsagittal line, around the third and fourth ventricles, often protruding into the lumen. They are positioned at the interface between the neuroparenchyma and the ventricular system of the brain. These highly vascularized nervous tissue structures differ from the brain parenchyma, as they lack a blood–brain barrier. Circumventricular organs have specialized sensory and secretory functions. It is essential for any pathologist who evaluates brain sections to have a solid knowledge of microscopic neuroanatomy and to recognize these numerous specialized structures within the nervous system as normal and not mistake them for pathological changes. The purpose of this study was to provide, for the first time, a detailed and complete histological description of the healthy canine area postrema and to determine its resemblance to that of other mammalian species. Anatomical dissections with routine histological and immunohistochemical techniques were carried out on ten canine brains. The cellular composition of area postrema proved to be largely comparable to that of other mammal species.
KW - Area postrema
KW - Circumventricular organs
KW - Dog
KW - Immunohistochemistry
KW - Morphology
UR - http://www.scopus.com/inward/record.url?scp=85008425522&partnerID=8YFLogxK
U2 - 10.1007/s12565-016-0388-0
DO - 10.1007/s12565-016-0388-0
M3 - Article
C2 - 28063139
VL - 93
SP - 188
EP - 196
JO - Anatomical Science International
JF - Anatomical Science International
SN - 1447-6959
IS - 2
ER -