Morphine is an opiate drug widely used as an analgesic in multiple medical diseases. Currently, its management in the maintenance treatment of opiate dependent patients is being studied. The most significant studies are described. In these, its usefulness has been assessed in comparison with other treatments, such as methadone, buprenorphine. Morphine has shown efficacy and tolerability. Its management is easy both in patients who consume heroin as well as those who have received other opiate drugs. Thus, it is a drug that may extend the therapeutic armamentarium in patients who begin with treatment with other opiates for the first time or who have previously received them. However, new studies must be conducted to adequately characterize its clinical use.