Morbidity of Cushing's Syndrome and Impact of Treatment

Susan M. Webb, Elena Valassi

Research output: Contribution to journalReview articleResearchpeer-review

20 Citations (Scopus)


© 2018 Elsevier Inc. Cortisol excess in Cushing's syndrome is associated with metabolic, cardiovascular, and cognitive alterations, only partially reversible after resolution of hypercortisolism. Elevated cardiovascular risk may persist after eucortisolism has been achieved. Fractures and low bone mineral density are also described in Cushing's syndrome in remission. Hypercortisolism may induce irreversible structural and functional changes in the brain, leading to neuropsychiatric disorders in the active phase of the disease, which persist. Sustained deterioration of the cardiovascular system, bone remodeling, and cognitive function along with neuropsychological impairment are associated with high morbidity and poor quality of life before and after remission.
Original languageEnglish
Pages (from-to)299-311
JournalEndocrinology and Metabolism Clinics of North America
Issue number2
Publication statusPublished - 1 Jun 2018


  • Cushing's syndrome
  • Morbidity
  • Quality of life
  • Remission


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