Monovalent cation transporters at the plasma membrane in yeasts

Joaquín Ariño, José Ramos, Hana Sychrova

Research output: Contribution to journalArticleResearch

29 Citations (Scopus)


© 2018 John Wiley & Sons, Ltd. Maintenance of proper intracellular concentrations of monovalent cations, mainly sodium and potassium, is a requirement for survival of any cell. In the budding yeast Saccharomyces cerevisiae, monovalent cation homeostasis is determined by the active extrusion of protons through the Pma1 H + -ATPase (reviewed in another chapter of this issue), the influx and efflux of these cations through the plasma membrane transporters (reviewed in this chapter), and the sequestration of toxic cations into the vacuoles. Here, we will describe the structure, function, and regulation of the plasma membrane transporters Trk1, Trk2, Tok1, Nha1, and Ena1, which play a key role in maintaining physiological intracellular concentrations of Na + , K + , and H + , both under normal growth conditions and in response to stress.
Original languageEnglish
Pages (from-to)177-193
Publication statusPublished - 1 Apr 2019


  • cation homeostasis
  • Ena1 ATPase
  • Nha1 antiporter
  • plasma membrane transport
  • Saccharomyces cerevisiae
  • Tok1
  • Trk potassium transporters
  • yeasts


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