TY - JOUR
T1 - Monoamine oxidase A (MAOA) interaction with parenting practices on callous-unemotional traits in preschoolers
AU - Navarro, J. B.
AU - Fatjó-Vilas, M.
AU - de la Osa, N.
AU - Penelo, E.
AU - Fañanás, L.
AU - Ezpeleta, L.
AU - Pueyo, N.
N1 - Publisher Copyright:
© 2021 Asociación Universitaria de Zaragoza para el Progreso de la Psiquiatría y la Salud Mental
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Background and Objectives: From a gene-by-environment perspective, parenting in interaction with the polymorphism in the Monoamine oxidase A (MAOA) gene (MAOA-uVNTR) might also be associated with increased callous-unemotional traits (CU) in preschoolers. MAOA-uVNTR results in differential enzyme activity, so that high-activity alleles (MAOA-H) are linked to reduced dopamine, serotonin, and norepinephrine availability in comparison to low-activity allele (MAOA-L). As MAOA-uVNTR has been previously described to moderate the relationship between childhood parental maltreatment and aggressive and antisocial behavior, it may also play a role in CU traits etiology. Methods: Data was collected through questionnaires answered by parents and teachers. MAOA-uVNTR was genotyped in 368 Caucasian children from a community sample (51.9% male). Multiple linear regression analyses were conducted to analyze the interaction effect of MAOA genotypes and both positive parenting and punitive parenting practices on CU traits at two different periods (3 and 5 years old) and separately by sex. Results: No significant interactions were found for boys. Among girls, a significant interaction effect was found for MAOA-LL carriers, who showed higher CU traits at age 5 when exposed to higher punitive or positive parenting at age 3. Conclusions: Our study provides the first evidence for significant MAOA × early parenting effects on CU traits in preschoolers, specifically among female MAOA-LL carriers. This suggests that the MAOA-LL genotype for girls is associated with higher sensitivity to both positive and punitive parenting in girls, so that MAOA-LL emerges as a genotype that confers higher vulnerability to parental influences.
AB - Background and Objectives: From a gene-by-environment perspective, parenting in interaction with the polymorphism in the Monoamine oxidase A (MAOA) gene (MAOA-uVNTR) might also be associated with increased callous-unemotional traits (CU) in preschoolers. MAOA-uVNTR results in differential enzyme activity, so that high-activity alleles (MAOA-H) are linked to reduced dopamine, serotonin, and norepinephrine availability in comparison to low-activity allele (MAOA-L). As MAOA-uVNTR has been previously described to moderate the relationship between childhood parental maltreatment and aggressive and antisocial behavior, it may also play a role in CU traits etiology. Methods: Data was collected through questionnaires answered by parents and teachers. MAOA-uVNTR was genotyped in 368 Caucasian children from a community sample (51.9% male). Multiple linear regression analyses were conducted to analyze the interaction effect of MAOA genotypes and both positive parenting and punitive parenting practices on CU traits at two different periods (3 and 5 years old) and separately by sex. Results: No significant interactions were found for boys. Among girls, a significant interaction effect was found for MAOA-LL carriers, who showed higher CU traits at age 5 when exposed to higher punitive or positive parenting at age 3. Conclusions: Our study provides the first evidence for significant MAOA × early parenting effects on CU traits in preschoolers, specifically among female MAOA-LL carriers. This suggests that the MAOA-LL genotype for girls is associated with higher sensitivity to both positive and punitive parenting in girls, so that MAOA-LL emerges as a genotype that confers higher vulnerability to parental influences.
KW - Gene by environment
KW - MAOA
KW - Development
KW - Preschool
KW - Parenting practices
KW - Callous unemotional traits
UR - https://dialnet.unirioja.es/servlet/articulo?codigo=8135520
UR - http://www.scopus.com/inward/record.url?scp=85112585774&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/f4d763b0-df12-3156-82e3-72797ec12a34/
U2 - 10.1016/j.ejpsy.2021.02.003
DO - 10.1016/j.ejpsy.2021.02.003
M3 - Article
AN - SCOPUS:85112585774
SN - 0213-6163
VL - 35
SP - 225
EP - 233
JO - European Journal of Psychiatry
JF - European Journal of Psychiatry
IS - 4
ER -