Molecular tweezers for enantiodiscrimination in NMR: Di-(R,R)-1-[10-(1- hydroxy-2,2,2-trifluoroethyl)-9-anthryl]-2,2, 2-trifluoroethyl benzenedicarboxylates

Sergio Gil, Martina Palomino-SchäTzlein, Kepa Koldo Burusco, Carlos Jaime, Albert Virgili

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9 Citations (Scopus)

Abstract

A series of new chiral molecular tweezers, di-(R,R)-1-[10-(1-hydroxy-2,2,2- trifluoroethyl)-9-anthryl]-2,2,2-trifluoroethyl phthalate (2), isophthalate (3) and terephthalate (4), were synthesized and their structure studied by NMR and molecular mechanics. Their effectiveness as chiral solvating agents for the determination of the enantiomeric purity of chiral compounds using NMR was demonstrated. © 2009 Wiley-Liss, Inc.
Original languageEnglish
Pages (from-to)548-556
JournalChirality
Volume22
Issue number6
DOIs
Publication statusPublished - 1 Jun 2010

Keywords

  • Chiral solvating agents
  • Enantiodiscrimination
  • Enantiomeric excess
  • Molecular tweezers
  • NMR

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