Molecular pathology of ovarian carcinomas

Xavier Matias-Guiu, Jaime Prat

Research output: Contribution to journalReview articleResearchpeer-review

38 Citations (Scopus)

Abstract

There is evidence that ovarian cancer may be derived from the progressive transformation of benign and/or borderline tumours. Mutations involving different oncogenes and tumour suppressor genes accumulate during the process of malignant transformation, and the alterations of genes involved in the pathogenesis of familial ovarian cancer are probably early events in ovarian tumorigenesis. BRCA-1 and BRCA-2 act as classical tumour suppressor genes in hereditary tumours, but their role in sporadic tumours remains controversial; however, a high frequency of allele losses in BRCA-1 (17q) and BRCA-2 (13q) loci has been observed in both familial and sporadic tumours. The possible role of mismatch repair genes and microsatellite instability is also controversial, but a role for them has been proposed in borderline tumours. Mutations in K-ras are specific for mucinous tumours and may be related to mucinous differentiation. Finally, a role in tumour progression has been proposed for both c-erb B-2 and p53, but their practical value in prognosis remains questionable.
Original languageEnglish
Pages (from-to)103-111
JournalVirchows Archiv
Volume433
Issue number2
DOIs
Publication statusPublished - 9 Sep 1998

Keywords

  • Oncogenes
  • Ovary
  • Pathogenesis
  • Tumour suppressor genes
  • Tumours

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