Molecular pathology of endometrial carcinoma

Xavier Matias-Guiu, Jaime Prat

    Research output: Contribution to journalReview articleResearchpeer-review

    123 Citations (Scopus)

    Abstract

    This review paper discusses the main molecular alterations of endometrial carcinoma, the most common cancer of the female genital tract. Two clinicopathological variants are recognized: the oestrogen-related (type I, endometrioid carcinoma) and the non-oestrogen-related (type II, non-endometrioid carcinoma). Whereas type I shows microsatellite instability and mutations in PTEN, PIK3CA, K-RAS and CTNNB1 (beta-catenin), type II exhibits TP53 mutations and chromosomal instability. Recent investigations regarding the role of non-coding RNA have provided important information regarding tumour progression. Understanding pathogenesis at the molecular level is essential for identifying biomarkers of potential use in targeted therapies. © 2012 Blackwell Publishing Limited.
    Original languageEnglish
    Pages (from-to)111-123
    JournalHistopathology
    Volume62
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2013

    Keywords

    • Apoptosis
    • Beta-catenin
    • Chromosomal instability
    • E-cadherin
    • Endometrial carcinoma
    • K-RAS
    • Microsatellite instability
    • Molecular genetics
    • PIK3CA
    • PTEN
    • TP53

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