Molecular genetics of endometrial carcinoma

Lluis Catasus, Alberto Gallardo, Jaime Prat

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

Two different clinicopathologic subtypes of endometrial carcinoma are recognized: the estrogen-related (type I, endometrioid) and the non-estrogen related (type II, non-endometrioid). The clinicopathological differences are paralleled by specific genetic alterations with type I showing microsatellite instability and mutations in PTEN, PIK3CA, K-RAS, and CTNNB1 (beta-catenin), and type II exhibiting p53 mutations and chromosomal instability. This article reviews the genetic changes of endometrial carcinogenesis in the light of morphologic features of the tumors and their precursors. © 2009 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)554-563
JournalDiagnostic Histopathology
Volume15
Issue number12
DOIs
Publication statusPublished - 1 Dec 2009

Keywords

  • beta-catenin
  • chromosomal instability
  • EEC
  • endometrial carcinoma
  • K-RAS
  • MI
  • NEEC
  • P53
  • PIK3CA
  • PTEN

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