Molecular genetics of endometrial carcinoma

Lluis Catasus; Alberto Gallardo; Jaime Prat

doi:10.1016/j.mpdhp.2009.09.002

Molecular genetics of endometrial carcinoma

Lluis Catasus, Alberto Gallardo, Jaime Prat

Department of Morphological Sciences

Research output: Contribution to journal › Article › Research › peer-review

21 Citations (Scopus)

Abstract

Two different clinicopathologic subtypes of endometrial carcinoma are recognized: the estrogen-related (type I, endometrioid) and the non-estrogen related (type II, non-endometrioid). The clinicopathological differences are paralleled by specific genetic alterations with type I showing microsatellite instability and mutations in PTEN, PIK3CA, K-RAS, and CTNNB1 (beta-catenin), and type II exhibiting p53 mutations and chromosomal instability. This article reviews the genetic changes of endometrial carcinogenesis in the light of morphologic features of the tumors and their precursors. © 2009 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	554-563
Journal	Diagnostic Histopathology
Volume	15
Issue number	12
DOIs	https://doi.org/10.1016/j.mpdhp.2009.09.002
Publication status	Published - 1 Dec 2009

Keywords

beta-catenin
chromosomal instability
EEC
endometrial carcinoma
K-RAS
MI
NEEC
P53
PIK3CA
PTEN

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10.1016/j.mpdhp.2009.09.002

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@article{58586088b8b0404da71b28321855a604,

title = "Molecular genetics of endometrial carcinoma",

abstract = "Two different clinicopathologic subtypes of endometrial carcinoma are recognized: the estrogen-related (type I, endometrioid) and the non-estrogen related (type II, non-endometrioid). The clinicopathological differences are paralleled by specific genetic alterations with type I showing microsatellite instability and mutations in PTEN, PIK3CA, K-RAS, and CTNNB1 (beta-catenin), and type II exhibiting p53 mutations and chromosomal instability. This article reviews the genetic changes of endometrial carcinogenesis in the light of morphologic features of the tumors and their precursors. {\textcopyright} 2009 Elsevier Ltd. All rights reserved.",

keywords = "beta-catenin, chromosomal instability, EEC, endometrial carcinoma, K-RAS, MI, NEEC, P53, PIK3CA, PTEN",

author = "Lluis Catasus and Alberto Gallardo and Jaime Prat",

year = "2009",

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day = "1",

doi = "10.1016/j.mpdhp.2009.09.002",

language = "English",

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TY - JOUR

T1 - Molecular genetics of endometrial carcinoma

AU - Catasus, Lluis

AU - Gallardo, Alberto

AU - Prat, Jaime

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Two different clinicopathologic subtypes of endometrial carcinoma are recognized: the estrogen-related (type I, endometrioid) and the non-estrogen related (type II, non-endometrioid). The clinicopathological differences are paralleled by specific genetic alterations with type I showing microsatellite instability and mutations in PTEN, PIK3CA, K-RAS, and CTNNB1 (beta-catenin), and type II exhibiting p53 mutations and chromosomal instability. This article reviews the genetic changes of endometrial carcinogenesis in the light of morphologic features of the tumors and their precursors. © 2009 Elsevier Ltd. All rights reserved.

AB - Two different clinicopathologic subtypes of endometrial carcinoma are recognized: the estrogen-related (type I, endometrioid) and the non-estrogen related (type II, non-endometrioid). The clinicopathological differences are paralleled by specific genetic alterations with type I showing microsatellite instability and mutations in PTEN, PIK3CA, K-RAS, and CTNNB1 (beta-catenin), and type II exhibiting p53 mutations and chromosomal instability. This article reviews the genetic changes of endometrial carcinogenesis in the light of morphologic features of the tumors and their precursors. © 2009 Elsevier Ltd. All rights reserved.

KW - beta-catenin

KW - chromosomal instability

KW - EEC

KW - endometrial carcinoma

KW - K-RAS

KW - MI

KW - NEEC

KW - P53

KW - PIK3CA

KW - PTEN

U2 - 10.1016/j.mpdhp.2009.09.002

DO - 10.1016/j.mpdhp.2009.09.002

M3 - Article

SN - 1756-2317

VL - 15

SP - 554

EP - 563

JO - Diagnostic Histopathology

JF - Diagnostic Histopathology

IS - 12

ER -

Molecular genetics of endometrial carcinoma

Abstract

Keywords

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