Molecular Evolution Bioinformatics Toward Structural Biology of TRPV1-4 Channels

Pau Doñate-Macián, Alba Crespi-Boixader, Alex Perálvarez-Marín

Research output: Contribution to journalArticleResearch


Bioinformatics is a very resourceful tool to understand evolution of membrane proteins, such as transient receptor potential channels. Expert bioinformatics users rely on specialized scripting and programming skills. Several web servers and standalone tools are available for nonadvanced users willing to develop projects to understand their system of choice. In this case, we present a desktop-based protocol to develop evostructural hypotheses based on basic bioinformatics skills and resources, specifically for a small subgroup of TRPV channels, which can be further implemented for larger datasets.
Original languageEnglish
Pages (from-to)1-21
JournalMethods in molecular biology (Clifton, N.J.)
Publication statusPublished - 1 Jan 2019


  • Computational structural biology
  • Evolutionary analysis
  • Evostructural studies
  • Membrane proteins
  • Phylogeny
  • Sequence–structure relationships
  • TRP channels


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