Molecular Epidemiology of Trypanosomatids and Trypanosoma cruzi in Primates from Peru

Esar Aysanoa; Pedro Mayor; A. Patricia Mendoza; Carlos M. Zariquiey; E. Angelo Morales; Jocelyn G. Pérez; Mark Bowler; Julio A. Ventocilla; Carlos González; G. Christian Baldeviano; Andrés G. Lescano

doi:10.1007/s10393-017-1271-8

Molecular Epidemiology of Trypanosomatids and Trypanosoma cruzi in Primates from Peru

Esar Aysanoa, Pedro Mayor, A. Patricia Mendoza, Carlos M. Zariquiey, E. Angelo Morales, Jocelyn G. Pérez, Mark Bowler, Julio A. Ventocilla, Carlos González, G. Christian Baldeviano, Andrés G. Lescano

Department of Animal Health and Anatomy

Research output: Contribution to journal › Article › Research › peer-review

13 Citations (Scopus)

Abstract

© 2017, EcoHealth Alliance. We determined the prevalence rate and risk of infection of Trypanosoma cruzi and other trypanosomatids in Peruvian non-human primates (NHPs) in the wild (n = 126) and in different captive conditions (n = 183). Blood samples were collected on filter paper, FTA cards, or EDTA tubes and tested using a nested PCR protocol targeting the 24Sα rRNA gene. Main risk factors associated with trypanosomatid and T. cruzi infection were genus and the human–animal context (wild vs captive animals). Wild NHPs had higher prevalence of both trypanosomatids (64.3 vs 27.9%, P OpenSPiltSPi 0.001) and T. cruzi (8.7 vs 3.3%, P = 0.057), compared to captive NHPs, suggesting that parasite transmission in NHPs occurs more actively in the sylvatic cycle. In terms of primate family, Pitheciidae had the highest trypanosomatid prevalence (20/22, 90.9%) and Cebidae had the highest T. cruzi prevalence (15/117, 12.8%). T. cruzi and trypanosomatids are common in Peruvian NHPs and could pose a health risk to human and animals that has not been properly studied.

Original language	English
Pages (from-to)	732-742
Journal	EcoHealth
Volume	14
Issue number	4
DOIs	https://doi.org/10.1007/s10393-017-1271-8
Publication status	Published - 1 Dec 2017

Keywords

Chagas
Epidemiology
Non-human primates
Prevalence
Trypanosoma cruzi
Trypanosomatids

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10393-017-1271-8

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title = "Molecular Epidemiology of Trypanosomatids and Trypanosoma cruzi in Primates from Peru",

abstract = "{\textcopyright} 2017, EcoHealth Alliance. We determined the prevalence rate and risk of infection of Trypanosoma cruzi and other trypanosomatids in Peruvian non-human primates (NHPs) in the wild (n = 126) and in different captive conditions (n = 183). Blood samples were collected on filter paper, FTA cards, or EDTA tubes and tested using a nested PCR protocol targeting the 24Sα rRNA gene. Main risk factors associated with trypanosomatid and T. cruzi infection were genus and the human–animal context (wild vs captive animals). Wild NHPs had higher prevalence of both trypanosomatids (64.3 vs 27.9%, P OpenSPiltSPi 0.001) and T. cruzi (8.7 vs 3.3%, P = 0.057), compared to captive NHPs, suggesting that parasite transmission in NHPs occurs more actively in the sylvatic cycle. In terms of primate family, Pitheciidae had the highest trypanosomatid prevalence (20/22, 90.9%) and Cebidae had the highest T. cruzi prevalence (15/117, 12.8%). T. cruzi and trypanosomatids are common in Peruvian NHPs and could pose a health risk to human and animals that has not been properly studied.",

keywords = "Chagas, Epidemiology, Non-human primates, Prevalence, Trypanosoma cruzi, Trypanosomatids",

author = "Esar Aysanoa and Pedro Mayor and Mendoza, {A. Patricia} and Zariquiey, {Carlos M.} and Morales, {E. Angelo} and P{\'e}rez, {Jocelyn G.} and Mark Bowler and Ventocilla, {Julio A.} and Carlos Gonz{\'a}lez and Baldeviano, {G. Christian} and Lescano, {Andr{\'e}s G.}",

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T1 - Molecular Epidemiology of Trypanosomatids and Trypanosoma cruzi in Primates from Peru

AU - Aysanoa, Esar

AU - Mayor, Pedro

AU - Mendoza, A. Patricia

AU - Zariquiey, Carlos M.

AU - Morales, E. Angelo

AU - Pérez, Jocelyn G.

AU - Bowler, Mark

AU - Ventocilla, Julio A.

AU - González, Carlos

AU - Baldeviano, G. Christian

AU - Lescano, Andrés G.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - © 2017, EcoHealth Alliance. We determined the prevalence rate and risk of infection of Trypanosoma cruzi and other trypanosomatids in Peruvian non-human primates (NHPs) in the wild (n = 126) and in different captive conditions (n = 183). Blood samples were collected on filter paper, FTA cards, or EDTA tubes and tested using a nested PCR protocol targeting the 24Sα rRNA gene. Main risk factors associated with trypanosomatid and T. cruzi infection were genus and the human–animal context (wild vs captive animals). Wild NHPs had higher prevalence of both trypanosomatids (64.3 vs 27.9%, P OpenSPiltSPi 0.001) and T. cruzi (8.7 vs 3.3%, P = 0.057), compared to captive NHPs, suggesting that parasite transmission in NHPs occurs more actively in the sylvatic cycle. In terms of primate family, Pitheciidae had the highest trypanosomatid prevalence (20/22, 90.9%) and Cebidae had the highest T. cruzi prevalence (15/117, 12.8%). T. cruzi and trypanosomatids are common in Peruvian NHPs and could pose a health risk to human and animals that has not been properly studied.

AB - © 2017, EcoHealth Alliance. We determined the prevalence rate and risk of infection of Trypanosoma cruzi and other trypanosomatids in Peruvian non-human primates (NHPs) in the wild (n = 126) and in different captive conditions (n = 183). Blood samples were collected on filter paper, FTA cards, or EDTA tubes and tested using a nested PCR protocol targeting the 24Sα rRNA gene. Main risk factors associated with trypanosomatid and T. cruzi infection were genus and the human–animal context (wild vs captive animals). Wild NHPs had higher prevalence of both trypanosomatids (64.3 vs 27.9%, P OpenSPiltSPi 0.001) and T. cruzi (8.7 vs 3.3%, P = 0.057), compared to captive NHPs, suggesting that parasite transmission in NHPs occurs more actively in the sylvatic cycle. In terms of primate family, Pitheciidae had the highest trypanosomatid prevalence (20/22, 90.9%) and Cebidae had the highest T. cruzi prevalence (15/117, 12.8%). T. cruzi and trypanosomatids are common in Peruvian NHPs and could pose a health risk to human and animals that has not been properly studied.

KW - Chagas

KW - Epidemiology

KW - Non-human primates

KW - Prevalence

KW - Trypanosoma cruzi

KW - Trypanosomatids

U2 - 10.1007/s10393-017-1271-8

DO - 10.1007/s10393-017-1271-8

M3 - Article

SN - 1612-9202

VL - 14

SP - 732

EP - 742

JO - EcoHealth

JF - EcoHealth

IS - 4

ER -

Molecular Epidemiology of Trypanosomatids and Trypanosoma cruzi in Primates from Peru

Abstract

Keywords

UN SDGs

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