Molecular determinants of invasion in endometrial cancer

M. Abal, M. Llauradá, A. Dolla, M. Monge, E. Colas, M. González, M. Rigau, H. Alazzouzi, S. Demajo, J. Castellví, A. García, S. Ramón y Cajal, J. Xercavins, M. H. Vázquez-Levin, F. Alameda, A. Gil-Moreno, J. Reventos

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)


Endometrial carcinoma is the most common gynaecological malignancy in the western world and the most frequent among infiltrating tumours of the female genital tract. Despite the characterisation of molecular events associated with the development of endometrial carcinoma, those associated with the early steps of infiltration and invasion in endometrial cancer are less known. Deep myometrial invasion correlates with more undifferentiated tumours, lymph-vascular invasion, node affectation and decreased global survival. In this review we present an overview of the molecular pathology of myometrial infiltration that defines the initial steps of invasion in endometrial cancer. Down-regulation of E-cadherin as a main player of epithelial to mesenchymal transition, as well as modifications on other molecules involved in cell-cell contacts, render cells with a migratory phenotype. In addition, altered signalling pathways and transcription factors associate with myometrial invasion, histologic grade and metastasis. © Feseo 2007.
Original languageEnglish
Pages (from-to)272-277
JournalClinical and Translational Oncology
Issue number5
Publication statusPublished - 1 Dec 2007


  • E-cadherin
  • Endometrial cancer
  • Epithelial to mesenchymal transition
  • ETV5
  • Metastasis
  • Myometrial infiltration
  • RUNX1


Dive into the research topics of 'Molecular determinants of invasion in endometrial cancer'. Together they form a unique fingerprint.

Cite this