Molecular characterization of atypical chronic myeloid leukemia and chronic neutrophilic leukemia

Alicia Senín, Leonor Arenillas, Luz Martínez-Avilés, Concepción Fernández-Rodríguez, Beatriz Bellosillo, Lourdes Florensa, Carles Besses, Alberto Álvarez-Larrán

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    Abstract

    © 2014 Elsevier España, S.L.U. Background and objective Atypical chronic myeloid leukemia (aCML) and chronic neutrophilic leukemia (CNL) display similar clinical and hematological characteristics. The objective of the present study was to determine the mutational status of SETBP1 and CSF3R in these diseases. Patients and method The mutational status of SETBP1 and CSF3R was studied in 7 patients with aCML (n = 3), CNL (n = 1) and unclassifiable myeloproliferative neoplasms (MPN-u) (n = 3). Additionally, mutations in ASXL1, SRSF2, IDH1/2, DNMT3A, and RUNX1 were also analyzed. Results SETBP1 mutations (G870S and G872R) were detected in 2 patients with MPN-u, and one of them also presented mutations in SRSF2 (P95H) and ASXL1 (E635fs). The CNL case showed mutations in CSFR3 (T618I), SETBP1 (G870S) and SRSF2 (P95H). No patient classified as aCML had mutations in SETBP1 or CSF3R. One of the patients with mutations evolved to acute myeloid leukemia, while the other 2 had disease progression without transformation to overt leukemia. Conclusion The knowledge of the molecular alterations involved in these rare diseases is useful in the diagnosis and may have an impact on both prognosis and therapy.
    Original languageEnglish
    Pages (from-to)487-490
    JournalMedicina Clinica
    Volume144
    Issue number11
    DOIs
    Publication statusPublished - 8 Jun 2015

    Keywords

    • Atypical chronic myeloid leukemia
    • Chronic neutrophilic leukemia
    • CSFR3
    • Myeloproliferative neoplasms
    • SETBP1

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  • Cite this

    Senín, A., Arenillas, L., Martínez-Avilés, L., Fernández-Rodríguez, C., Bellosillo, B., Florensa, L., Besses, C., & Álvarez-Larrán, A. (2015). Molecular characterization of atypical chronic myeloid leukemia and chronic neutrophilic leukemia. Medicina Clinica, 144(11), 487-490. https://doi.org/10.1016/j.medcli.2014.03.020