Molecular biology of bone metastases

Andreas Doll, Marta García, Marina Rigau, Mireia Olivan, Melania Montes, Tamara Sequeiros, Marta Llaurado, Eva Colás, Jaume Reventós, Juan Morote

Research output: Contribution to journalReview articleResearchpeer-review

1 Citation (Scopus)


Bone metastases are a frequent and devastating complication in cancer patients. Recently, significant advances in our understanding of the molecular mechanisms responsible for both osteolytic and osteoblastic bone metastases have occurred. The use of OMICS and the availability of appropriate preclinical animal models of bone metastasis have permitted the identification of factors produced by the tumor or by the host stroma in response to the tumor. These types of studies should result in a decrease of the serious skeletal morbidities associated with metastatic prostate cancer and may in the future improve overall survival. In this review the next generation of molecular targets in bone metastasis will be summarized.
Original languageEnglish
Pages (from-to)463-474
JournalArchivos Espanoles de Urologia
Issue number5
Publication statusPublished - 1 Jun 2013


  • Bone metastases
  • Molecular biology
  • Prostate cancer


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