Modulation of gastric accommodation by duodenal nutrients

Mauricio Carrasco, Fernando Azpiroz, Juan R. Malagelada

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13 Citations (Scopus)


Aim: To determine the relative potency and contribution of intestinal nutrients to net gastric accommodative relaxation and conscious perception. Methods: In 12 healthy subjects, we randomly tested duodenal loads of lipids and carbohydrates (12 mL administered in 4 min) at various caloric concentrations (0.0125-0.8 kcal/mL) separated by 12-24 min wash-out periods of saline infusion. Maximal gastric relaxation was induced at the end of each experiment by i.v glucagon (5 μg/kg), as reference. The reflex gastric response was measured by a barostat, and symptom perception by a 0-6 score questionnaire. Results: Lipids induced a dose-response gastric relaxation with a steep and early rise. Maximal effect (179±42 mL relaxation) reached at a relatively low concentration (0.2 kcal/mL), maximal lipid-induced relaxation was 61±6% of the glucagon effect. By contrast, duodenal infusion of carbohydrates induced weaker relaxation that became significant only at the high end of the physiological concentration range (65±14 mL with 0.8 kcal/mL). Intestinal nutrient loads, either of lipid or carbohydrates, did not induce significant changes in perception (0.6±0.4 and 0.1±0.4 score increase for the highest concentrations, respectively). Conclusion: Chyme entering the small bowel induces nutrient-specific gastric relaxatory reflexes by a physiologically saturable mechanism. Normally, neither the intestinal nutrient load nor the gastric accommodative response is perceived. © 2005 The WJG Press and Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)4848-4851
JournalWorld Journal of Gastroenterology
Issue number31
Publication statusPublished - 21 Aug 2005


  • Enterogastric reflex
  • Gastric accommodation
  • Gastric barostat
  • Gastric relaxation
  • Gut perception
  • Intestinal nutrients
  • Postprandial symptoms


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