1. 1. The effect of fenitrothion on testicular microsomal system was analyzed and compared to the modifications induced by the drug at the hepatic level. 2. 2. Acute (165 mg/kg, 1 day) and subacute (55 mg/kg, 3 days) administration of fenitrothion caused a significant decrease on testicular cytochrome P-450 content (51 and 50% respectively) but no modification on cytochrome b5 and NADPH cytochrome c reductase. No changes were induced by fenitrothion in testicular microsomal system after chronic treatment (5.5 mg/ml, 30 days). 3. 3. Results obtained in the liver were very similar to those observed in testis even though the percentage of cytochrome P-450 inhibition obtained after acute and subacute drug administration (45 and 43%) was smaller. 4. 4. In addition, changes in testosterone blood concentrations were also analyzed. A significant reduction of hormone plasma levels were detected at 165 and 55 mg/kg doses of fenitrothion (98% in both cases). Fenitrothion was not able to modify the levels of testosterone in the blood after chronic administration. © 1994.
|Publication status||Published - 1 Jan 1994|
Clos, M. V., Ramoneda, M., & Garcia, G. (1994). Modification of testicular cytochrome P-450 after fenitrothion administration. General Pharmacology, 25(3), 499-503. https://doi.org/10.1016/0306-3623(94)90205-4