Modelling multiple sclerosis using induced pluripotent stem cells

Júlia Martínez-Larrosa, Clara Matute-Blanch, Xavier Montalban, Manuel Comabella*

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

5 Citations (Scopus)


Multiple Sclerosis (MS) is one of the leading causes of non-traumatic neurological disability among young adults. Due to its complex pathology and the lack of reliable disease models, there are no effective therapies for MS to prevent neurodegeneration or promote neuroprotection, and hence stop disease progression. The emergence of induced pluripotent stem cells (iPSC) has allowed the generation of patient-specific neural cell types for disease modelling, drug screening, and cell therapy. In this review, the challenges related with the use of iPSC-derived cells in MS are discussed, with a special focus on the functional studies performed, limitations and future perspectives.

Original languageEnglish
Article number577425
JournalJournal of Neuroimmunology
Publication statusPublished - 15 Dec 2020


  • Induced pluripotent stem cells
  • Multiple sclerosis
  • Neurodegeneration
  • Neuroprotection


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