Modeling cooperativity effects in dimeric G protein-coupled receptors

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Abstract

G protein-coupled receptors organize into oligomeric arrangements to exert their function. In this chapter, three models of dimeric receptors, the two-state dimer receptor model, the metabotropic glutamate receptor model, and the asymmetric/symmetric three-state dimer receptor model are revisited focusing on the cooperative effects between their binding sites and the subunits they are composed of. The mathematical analysis reveals the complexity of the intra-receptor interactions providing insights on the mechanistic aspects of receptor function. © 2013 Elsevier Inc.
Original languageEnglish
Title of host publicationProgress in Molecular Biology and Translational Science
Pages349-373
Number of pages24
Volume115
DOIs
Publication statusPublished - 1 Jan 2013

Keywords

  • Allosterism
  • Cooperativity
  • Dimer receptors
  • GPCR
  • Keywords
  • Mathematical modeling
  • Receptor oligomerization

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