Modeling amyloids in bacteria

Anna Villar-Piqué; Salvador Ventura

doi:10.1186/1475-2859-11-166

Modeling amyloids in bacteria

Anna Villar-Piqué, Salvador Ventura^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

24 Citations (Scopus)

Abstract

An increasing number of proteins are being shown to assemble into amyloid structures, self-seeding fibrillar aggregates that may lead to pathological states or play essential biological functions in organisms. Bacterial cell factories have raised as privileged model systems to understand the mechanisms behind amyloid assembly and the cellular fitness cost associated to the formation of these aggregates. In the near future, these bacterial systems will allow implementing high-throughput screening approaches to identify effective modulators of amyloid aggregation.

Original language	English
Article number	166
Number of pages	3
Journal	Microbial cell factories (Print)
Volume	11
DOIs	https://doi.org/10.1186/1475-2859-11-166
Publication status	Published - 28 Dec 2012

Access to Document

10.1186/1475-2859-11-166

https://ddd.uab.cat/record/225172

Cite this

@article{94d99894cc8b4be8a17c555d4c5a2b6e,

title = "Modeling amyloids in bacteria",

abstract = "An increasing number of proteins are being shown to assemble into amyloid structures, self-seeding fibrillar aggregates that may lead to pathological states or play essential biological functions in organisms. Bacterial cell factories have raised as privileged model systems to understand the mechanisms behind amyloid assembly and the cellular fitness cost associated to the formation of these aggregates. In the near future, these bacterial systems will allow implementing high-throughput screening approaches to identify effective modulators of amyloid aggregation.",

author = "Anna Villar-Piqu{\'e} and Salvador Ventura",

note = "Funding Information: Work in our lab is supported by grants BFU2010-14901 from Ministerio de Ciencia e Innovaci{\'o}n (Spain) and 2009-SGR 760 from AGAUR (Generalitat de Catalunya). SV has been granted an ICREA ACADEMIA award (ICREA).",

year = "2012",

month = dec,

day = "28",

doi = "10.1186/1475-2859-11-166",

language = "English",

volume = "11",

}

TY - JOUR

T1 - Modeling amyloids in bacteria

AU - Villar-Piqué, Anna

AU - Ventura, Salvador

N1 - Funding Information: Work in our lab is supported by grants BFU2010-14901 from Ministerio de Ciencia e Innovación (Spain) and 2009-SGR 760 from AGAUR (Generalitat de Catalunya). SV has been granted an ICREA ACADEMIA award (ICREA).

PY - 2012/12/28

Y1 - 2012/12/28

N2 - An increasing number of proteins are being shown to assemble into amyloid structures, self-seeding fibrillar aggregates that may lead to pathological states or play essential biological functions in organisms. Bacterial cell factories have raised as privileged model systems to understand the mechanisms behind amyloid assembly and the cellular fitness cost associated to the formation of these aggregates. In the near future, these bacterial systems will allow implementing high-throughput screening approaches to identify effective modulators of amyloid aggregation.

AB - An increasing number of proteins are being shown to assemble into amyloid structures, self-seeding fibrillar aggregates that may lead to pathological states or play essential biological functions in organisms. Bacterial cell factories have raised as privileged model systems to understand the mechanisms behind amyloid assembly and the cellular fitness cost associated to the formation of these aggregates. In the near future, these bacterial systems will allow implementing high-throughput screening approaches to identify effective modulators of amyloid aggregation.

UR - https://www.scopus.com/pages/publications/84872185872

U2 - 10.1186/1475-2859-11-166

DO - 10.1186/1475-2859-11-166

M3 - Article

C2 - 23272903

AN - SCOPUS:84872185872

SN - 1475-2859

VL - 11

JO - Microbial cell factories (Print)

JF - Microbial cell factories (Print)

M1 - 166

ER -

Modeling amyloids in bacteria

Abstract

Access to Document

Other files and links

Fingerprint

Una visión integrada de la agregación proteica: analisis in silico, in vitro, celular, transcriptomico y proteomico (INTAG)

Cite this

Modeling amyloids in bacteria

Abstract

Access to Document

Other files and links

Fingerprint

Projects

Una visión integrada de la agregación proteica: analisis in silico, in vitro, celular, transcriptomico y proteomico (INTAG)

Cite this