MiRNA-targeted therapies in the most prevalent pediatric solid tumors

Josep Roma, Ana Almazán-Moga, José Sánchez De Toledo, Soledad Gallego, Miguel F. Segura

Research output: Chapter in BookChapterResearchpeer-review

2 Citations (Scopus)

Abstract

© Springer International Publishing Switzerland 2014. All rights reserved. Childhood cancers differ greatly from adult malignancies owing to their different etiology, biology, response to treatment and outcome. While adult tumors are mostly of epithelial origin and linked to a sustained exposure to environmental carcinogenic agents, pediatric malignancies tend to be of hematologic, mesenchymal or nervous system origin and their etiology is often unknown. Despite the small number of cases of childhood versus adult cancers, great advances have been made in treatment protocols in the last three decades. However, cancer remains the second cause of childhood mortality. Metastatic disease and acquired resistance to therapy continue to pose two major challenges for long-term cure. However, alternatives to classical chemo- and radiotherapy are emerging. MicroRNAs (miRNAs) are small endogenous non-coding RNAs that interfere with the translation and stability of coding messenger RNAs in a sequence-specific manner. In recent years, miRNAs have been found to be deregulated in a number of adult and pediatric malignancies and their restoration opens up an attractive new therapeutic approach. This chapter will review the discovery of miRNAs that can be therapeutic targets for the most prevalent pediatric solid tumors.
Original languageEnglish
Title of host publicationMicroRNA Targeted Cancer Therapy
Pages239-263
Number of pages24
DOIs
Publication statusPublished - 1 Feb 2014

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