Mild hypothermia protects against oxygen glucose deprivation (OGD)-induced cell death in brain slices from adult mice

Mar Hernández-Guillamon; Laura Ortega; Cristina Merino-Zamorano; Mireia Campos-Martorell; Anna Rosell; Joan Montaner

doi:10.1007/s00702-013-1090-1

Mild hypothermia protects against oxygen glucose deprivation (OGD)-induced cell death in brain slices from adult mice

Mar Hernández-Guillamon, Laura Ortega, Cristina Merino-Zamorano, Mireia Campos-Martorell, Anna Rosell, Joan Montaner

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Abstract

Most of neuroprotective strategies in stroke have failed to move from bench to bedside. One explanation might be the use of excessive uniform and smooth experimental models. Therefore, we have employed a more stringent in vitro model based on cultured brain slices from adult mice submitted to OGD. Using this acute model, we have confirmed that mild hypothermia protects against OGD-induced cell death when cooling the tissue during and after OGD, but not when hypothermia is induced only during reoxygenation. © 2013 Springer-Verlag Wien.

Original language	English
Pages (from-to)	113-117
Journal	Journal of Neural Transmission
Volume	121
Issue number	2
DOIs	https://doi.org/10.1007/s00702-013-1090-1
Publication status	Published - 1 Feb 2014

Keywords

Brain slices
Cerebral ischemia
Hypothermia
OGD
Oxygen glucose deprivation
Stroke

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10.1007/s00702-013-1090-1

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title = "Mild hypothermia protects against oxygen glucose deprivation (OGD)-induced cell death in brain slices from adult mice",

abstract = "Most of neuroprotective strategies in stroke have failed to move from bench to bedside. One explanation might be the use of excessive uniform and smooth experimental models. Therefore, we have employed a more stringent in vitro model based on cultured brain slices from adult mice submitted to OGD. Using this acute model, we have confirmed that mild hypothermia protects against OGD-induced cell death when cooling the tissue during and after OGD, but not when hypothermia is induced only during reoxygenation. {\textcopyright} 2013 Springer-Verlag Wien.",

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T1 - Mild hypothermia protects against oxygen glucose deprivation (OGD)-induced cell death in brain slices from adult mice

AU - Hernández-Guillamon, Mar

AU - Ortega, Laura

AU - Merino-Zamorano, Cristina

AU - Campos-Martorell, Mireia

AU - Rosell, Anna

AU - Montaner, Joan

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Most of neuroprotective strategies in stroke have failed to move from bench to bedside. One explanation might be the use of excessive uniform and smooth experimental models. Therefore, we have employed a more stringent in vitro model based on cultured brain slices from adult mice submitted to OGD. Using this acute model, we have confirmed that mild hypothermia protects against OGD-induced cell death when cooling the tissue during and after OGD, but not when hypothermia is induced only during reoxygenation. © 2013 Springer-Verlag Wien.

AB - Most of neuroprotective strategies in stroke have failed to move from bench to bedside. One explanation might be the use of excessive uniform and smooth experimental models. Therefore, we have employed a more stringent in vitro model based on cultured brain slices from adult mice submitted to OGD. Using this acute model, we have confirmed that mild hypothermia protects against OGD-induced cell death when cooling the tissue during and after OGD, but not when hypothermia is induced only during reoxygenation. © 2013 Springer-Verlag Wien.

KW - Brain slices

KW - Cerebral ischemia

KW - Hypothermia

KW - OGD

KW - Oxygen glucose deprivation

KW - Stroke

U2 - 10.1007/s00702-013-1090-1

DO - 10.1007/s00702-013-1090-1

M3 - Article

VL - 121

SP - 113

EP - 117

IS - 2

ER -

Mild hypothermia protects against oxygen glucose deprivation (OGD)-induced cell death in brain slices from adult mice

Abstract

Keywords

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