Mild hypothermia protects against oxygen glucose deprivation (OGD)-induced cell death in brain slices from adult mice

Mar Hernández-Guillamon, Laura Ortega, Cristina Merino-Zamorano, Mireia Campos-Martorell, Anna Rosell, Joan Montaner

    Research output: Contribution to journalArticleResearchpeer-review

    2 Citations (Scopus)

    Abstract

    Most of neuroprotective strategies in stroke have failed to move from bench to bedside. One explanation might be the use of excessive uniform and smooth experimental models. Therefore, we have employed a more stringent in vitro model based on cultured brain slices from adult mice submitted to OGD. Using this acute model, we have confirmed that mild hypothermia protects against OGD-induced cell death when cooling the tissue during and after OGD, but not when hypothermia is induced only during reoxygenation. © 2013 Springer-Verlag Wien.
    Original languageEnglish
    Pages (from-to)113-117
    JournalJournal of Neural Transmission
    Volume121
    Issue number2
    DOIs
    Publication statusPublished - 1 Feb 2014

    Keywords

    • Brain slices
    • Cerebral ischemia
    • Hypothermia
    • OGD
    • Oxygen glucose deprivation
    • Stroke

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