Most of neuroprotective strategies in stroke have failed to move from bench to bedside. One explanation might be the use of excessive uniform and smooth experimental models. Therefore, we have employed a more stringent in vitro model based on cultured brain slices from adult mice submitted to OGD. Using this acute model, we have confirmed that mild hypothermia protects against OGD-induced cell death when cooling the tissue during and after OGD, but not when hypothermia is induced only during reoxygenation. © 2013 Springer-Verlag Wien.
|Journal||Journal of Neural Transmission|
|Publication status||Published - 1 Feb 2014|
- Brain slices
- Cerebral ischemia
- Oxygen glucose deprivation