Microvascular disorders in obese Zucker rats are restored by a rice bran diet

M. L. Justo, C. Claro, E. Vila, M. D. Herrera, R. Rodriguez-Rodriguez

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

Background and aim: Nutritional-based approaches aimed to prevent microvascular dysfunction associated to obesity present potential advantages over pharmacological strategies. Our aim was to test whether a rice bran enzymatic extract (RBEE)-supplemented diet could attenuate microvascular alterations in obese rats. Methods and results: Lean and obese Zucker rats were fed standard diet supplemented or not with 1% and 5% RBEE for 20 weeks. Functional studies were performed in small mesenteric arteries in isometric myograph. Immunoblotting and fluorescence studies were made in arterial homogenates and arterial sections, respectively. RBEE-supplementation restored microvascular function in obese rats through a marked increase in NO and endothelial-derived hyperpolarizing factor contribution by up-regulation of eNOS and calcium-activated potassium channels expression, respectively, in association to a substantial reduction of microvascular inflammation and superoxide anion formation. These data agrees with the beneficial actions of RBEE on dyslipidemia, hyperinsulinemia and hypertension in obesity. Conclusion: The multi-factorial properties of RBEE-diet, especially for restoring the function of small resistance arteries shows this dietary-based approach to be a promising candidate for prevention of microvascular alterations in obesity, which are crucial in cardiovascular events in obese subjects. © 2013 Elsevier B.V.
Original languageEnglish
Pages (from-to)524-531
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume24
Issue number5
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Mesenteric artery
  • Microvascular function
  • Obese zucker rat
  • Obesity
  • Rice bran

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