The in vitro antifungal activity of a new imidazole derivative, flutrimazole (UR-4059) has been compared with that of clotrimazole, against 114 Candida strains, 45 dermatophyte strains and 28 opportunistic moulds. A standardized two-fold dilution method was used with Sabouraud glucose broth plus gentamicine. The range of antifungal drugs used varied between 40 and 0.015 μg/ml. Readings were made at 48 hours for yeast strains, 7 days for dermatophytes, and 3 days for opportunistic moulds. Results showed a susceptibility to flutrimazole of between 0.3 and 10 μg/ml for Candida albicans, 0.6 and 10 μg/ml for Candida tropicalis, below this range for Candida guilliermondii; irregular results were obtained for Candida parapsilosis, Candida krusei and Candida glabrata. The minimal inhibitory concentration (MIC) values of flutrimazole were higher than those of clotrimazole against dermatophytes, but not against opportunistic moulds, except for the Fusarium species studied. In this last case, flutrimazole showed an in vitro antifungal activity within a similar range to that of clotrimazole.
|Journal||Journal de Mycologie Medicale|
|Publication status||Published - 1 Jan 1994|
- antifungal activity
- opportunistic moulds