Microchip-based electrochromatography: Designs and applications

Martin Pumera

Research output: Contribution to journalArticleResearchpeer-review

87 Citations (Scopus)

Abstract

Different techniques and methods of electrochromatography on "lab on a chip" devices are reviewed. Described approaches include open-channel microchip electrochromatography relying on C8, C18 and novel gold nanoparticle (GNP) coating of microchannel wall; packed-channel microchip electrochromatography with new ways of automated loading and unloading of conventional octadecylsilica beads; monolith-based microchip electrochromatography with tailored casting of stationary phase at the specific places of microfluidic network and novel photolitographically fabricated collocated monolithic structures. Specific issues related to the microchip electrochromatography, i.e. importance of high aspect ratio of the microchannels in the open-channel electrochromatography or approaches eliminating the wall effect in the monolith-based electrochromatography, are discussed. Various applications for environmental, pharmacological, genomic and proteomic analysis are described. The operation parameters of reviewed microsystems are summarized in easy-to-read tables. © 2005 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)1048-1062
JournalTalanta
Volume66
Issue number4
DOIs
Publication statusPublished - 15 May 2005

Keywords

  • Coating
  • DNA
  • Electrochromatography
  • Microchip
  • Miniaturization
  • Monolith
  • Packing material
  • Peptides
  • Review

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