Mice with pulmonary tuberculosis treated with Mycobacterium vaccae develop strikingly enhanced recall gamma interferon responses to M. vaccae cell wall skeleton

Elisabeth Rodríguez-Güell, Gemma Agustí, Mercè Corominas, Pere Joan Cardona, Marina Luquin, Esther Julián

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Whole heat-killed Mycobacterium vaccae is used as an immunotherapeutic agent in tuberculosis (TB), but the compound(s) that triggers its immunostimulatory ability is not known. Here, we show that among different subcellular fractions, the cell wall skeleton induced a prominent expression of gamma interferon in splenocytes from both non-TB and TB M. vaccae-treated mice. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Original languageEnglish
Pages (from-to)893-896
JournalClinical and Vaccine Immunology
Volume15
DOIs
Publication statusPublished - 1 May 2008

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