Methylxanthines reverse the adipsic and aphagic syndrome induced by bilateral 6-hydroxydopamine lesions of the nigrostriatal pathway in rats

M. Casas, G. Prat, P. Robledo, M. Barbanoj, J. Kulisevsky, F. Jané

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15 Citations (Scopus)

Abstract

This study investigated whether methylxanthines (caffeine and theophylline) would restore food and water intake in rats made aphagic and adipsic by bilateral 6-hydroxydopamine lesions of the nigrostriatal bundle, and these results were compared with the effects of d-amphetamine, the dopamine D1 agonist SKF 38393, and the D(2/3) agonist quinpirole. In a separate experiment, we investigated whether the selective D1 antagonist, SCH 23390, or the selective D2 antagonist, sulpiride, would prevent the caffeine-induced restoration of food and water intake in bilaterally 6-hydroxydopamine denervated rats. The results showed that caffeine, theophylline, and quinpirole significantly reversed the aphagia and adipsia observed in lesioned animals. SKF 38393 had no significant effects on water intake, while it significantly restored food intake at the highest dose used. In contrast, d-amphetamine had no significant effects on food or water intake. Results from the second experiment showed that sulpiride attenuated the caffeine-induced restoration of food and water intake in lesioned rats to a greater extent than did SCH 23390. These data suggest that methylxanthines may mediate their effects on food and water intake in bilateral 6-hydroxydopamine-lesioned rats through an action at the dopaminergic system. © 2000 Elsevier Science Inc.
Original languageEnglish
Pages (from-to)257-263
JournalPharmacology Biochemistry and Behavior
Volume66
DOIs
Publication statusPublished - 1 Jan 2000

Keywords

  • Caffeine
  • Dopamine Antagonists
  • Dopamine agonists
  • Food and water intake
  • Quinpirole
  • SCH23390
  • SKF 38393
  • Sulpiride
  • Theophylline

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