Methylclock: A Bioconductor package to estimate DNA methylation age methylclock: A Bioconductor package to estimate DNA methylation age

Dolors Pelegi-Siso; Paula De Prado; Justiina Ronkainen; Mariona Bustamante; Juan R. Gonzalez

doi:10.1093/bioinformatics/btaa825

Methylclock: A Bioconductor package to estimate DNA methylation age methylclock: A Bioconductor package to estimate DNA methylation age

Dolors Pelegi-Siso, Paula De Prado, Justiina Ronkainen, Mariona Bustamante, Juan R. Gonzalez^*

^*Corresponding author for this work

Universitat Autònoma de Barcelona (UAB)

Research output: Contribution to journal › Article › Research › peer-review

71 Citations (Scopus)

Abstract

Motivation: Ageing is a biological and psychosocial process related to diseases and mortality. It correlates with changes in DNA methylation (DNAm) in all human tissues. Therefore, epigenetic markers can be used to estimate biological age using DNAm profiling across tissues. Results: We developed a Bioconductor package that allows computation of several existing DNAm adult/childhood and gestational age clocks. Functions to visualize the DNAm age prediction versus chronological age and the correlation between DNAm clocks are also available as well as other features, such as missing data imputation of cell types' estimates, that are required for DNAm age clocks.

Original language	English
Pages (from-to)	1759-1760
Number of pages	2
Journal	Bioinformatics
Volume	37
Issue number	12
DOIs	https://doi.org/10.1093/bioinformatics/btaa825
Publication status	Published - 15 Jun 2021

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abstract = "Motivation: Ageing is a biological and psychosocial process related to diseases and mortality. It correlates with changes in DNA methylation (DNAm) in all human tissues. Therefore, epigenetic markers can be used to estimate biological age using DNAm profiling across tissues. Results: We developed a Bioconductor package that allows computation of several existing DNAm adult/childhood and gestational age clocks. Functions to visualize the DNAm age prediction versus chronological age and the correlation between DNAm clocks are also available as well as other features, such as missing data imputation of cell types' estimates, that are required for DNAm age clocks.",

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T2 - A Bioconductor package to estimate DNA methylation age methylclock: A Bioconductor package to estimate DNA methylation age

AU - Pelegi-Siso, Dolors

AU - De Prado, Paula

AU - Ronkainen, Justiina

AU - Bustamante, Mariona

AU - Gonzalez, Juan R.

PY - 2021/6/15

Y1 - 2021/6/15

N2 - Motivation: Ageing is a biological and psychosocial process related to diseases and mortality. It correlates with changes in DNA methylation (DNAm) in all human tissues. Therefore, epigenetic markers can be used to estimate biological age using DNAm profiling across tissues. Results: We developed a Bioconductor package that allows computation of several existing DNAm adult/childhood and gestational age clocks. Functions to visualize the DNAm age prediction versus chronological age and the correlation between DNAm clocks are also available as well as other features, such as missing data imputation of cell types' estimates, that are required for DNAm age clocks.

AB - Motivation: Ageing is a biological and psychosocial process related to diseases and mortality. It correlates with changes in DNA methylation (DNAm) in all human tissues. Therefore, epigenetic markers can be used to estimate biological age using DNAm profiling across tissues. Results: We developed a Bioconductor package that allows computation of several existing DNAm adult/childhood and gestational age clocks. Functions to visualize the DNAm age prediction versus chronological age and the correlation between DNAm clocks are also available as well as other features, such as missing data imputation of cell types' estimates, that are required for DNAm age clocks.

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U2 - 10.1093/bioinformatics/btaa825

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VL - 37

SP - 1759

EP - 1760

JO - Bioinformatics

JF - Bioinformatics

IS - 12

ER -

Methylclock: A Bioconductor package to estimate DNA methylation age methylclock: A Bioconductor package to estimate DNA methylation age

Abstract

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