Methotrexate pharmacokinetic genetic variants are associated with outcome in rheumatoid arthritis patients

Patricia Moya; Juliana Salazar; María Jesús Arranz; César Díaz-Torné; Elisabeth Del Río; Jordi Casademont; Hèctor Corominas; Montserrat Baiget

doi:10.2217/pgs.15.150

Methotrexate pharmacokinetic genetic variants are associated with outcome in rheumatoid arthritis patients

Patricia Moya, Juliana Salazar, María Jesús Arranz, César Díaz-Torné, Elisabeth Del Río, Jordi Casademont, Hèctor Corominas, Montserrat Baiget

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

25 Citations (Scopus)

Abstract

© 2016 Future Medicine Ltd. Background: Methotrexate (MTX) is the most used drug for the treatment of rheumatoid arthritis (RA) although outcome differs among patients. Aim: To evaluate whether polymorphisms in pharmacokinetic genes are associated with outcome in RA patients receiving MTX. Patients & methods: We analyzed 28 SNPs in SLC19A1/RFC1, ABCB1, FPGS and GGH genes. Results: We studied 194 RA patients receiving MTX monotherapy. Two FPGS SNPs, rs10987742 and rs10106, were associated with response (p = 0.033 and p = 0.041, respectively). The FPGS rs10106 variant was also associated with MTX survival (p = 0.005) and toxicity (p = 0.021). Three ABCB1 SNPs, rs868755, rs10280623 and rs1858923, were associated with toxicity (p = 0.025, p = 0.048 and p = 0.031, respectively). Conclusion: FPGS and ABCB1 genetic variants can influence the outcome in RA patients receiving MTX monotherapy.

Original language	English
Pages (from-to)	11-25
Journal	Pharmacogenomics
Issue number	1
DOIs	https://doi.org/10.2217/pgs.15.150
Publication status	Published - 1 Jan 2016

Keywords

ABCB1
FPGS
GGH
methotrexate
pharmacogenetics
rheumatoid arthritis
SLC19A1/RFC1

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@article{c5812eafda684bb0a1b0a7807833af60,

title = "Methotrexate pharmacokinetic genetic variants are associated with outcome in rheumatoid arthritis patients",

abstract = "{\textcopyright} 2016 Future Medicine Ltd. Background: Methotrexate (MTX) is the most used drug for the treatment of rheumatoid arthritis (RA) although outcome differs among patients. Aim: To evaluate whether polymorphisms in pharmacokinetic genes are associated with outcome in RA patients receiving MTX. Patients & methods: We analyzed 28 SNPs in SLC19A1/RFC1, ABCB1, FPGS and GGH genes. Results: We studied 194 RA patients receiving MTX monotherapy. Two FPGS SNPs, rs10987742 and rs10106, were associated with response (p = 0.033 and p = 0.041, respectively). The FPGS rs10106 variant was also associated with MTX survival (p = 0.005) and toxicity (p = 0.021). Three ABCB1 SNPs, rs868755, rs10280623 and rs1858923, were associated with toxicity (p = 0.025, p = 0.048 and p = 0.031, respectively). Conclusion: FPGS and ABCB1 genetic variants can influence the outcome in RA patients receiving MTX monotherapy.",

keywords = "ABCB1, FPGS, GGH, methotrexate, pharmacogenetics, rheumatoid arthritis, SLC19A1/RFC1",

author = "Patricia Moya and Juliana Salazar and Arranz, {Mar{\'i}a Jes{\'u}s} and C{\'e}sar D{\'i}az-Torn{\'e} and {Del R{\'i}o}, Elisabeth and Jordi Casademont and H{\`e}ctor Corominas and Montserrat Baiget",

year = "2016",

month = jan,

day = "1",

doi = "10.2217/pgs.15.150",

language = "English",

pages = "11--25",

journal = "Pharmacogenomics",

issn = "1462-2416",

publisher = "Future Medicine Ltd.",

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Methotrexate pharmacokinetic genetic variants are associated with outcome in rheumatoid arthritis patients. / Moya, Patricia; Salazar, Juliana; Arranz, María Jesús; Díaz-Torné, César; Del Río, Elisabeth; Casademont, Jordi; Corominas, Hèctor; Baiget, Montserrat.

In: Pharmacogenomics, No. 1, 01.01.2016, p. 11-25.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Methotrexate pharmacokinetic genetic variants are associated with outcome in rheumatoid arthritis patients

AU - Moya, Patricia

AU - Salazar, Juliana

AU - Arranz, María Jesús

AU - Díaz-Torné, César

AU - Del Río, Elisabeth

AU - Casademont, Jordi

AU - Corominas, Hèctor

AU - Baiget, Montserrat

PY - 2016/1/1

Y1 - 2016/1/1

N2 - © 2016 Future Medicine Ltd. Background: Methotrexate (MTX) is the most used drug for the treatment of rheumatoid arthritis (RA) although outcome differs among patients. Aim: To evaluate whether polymorphisms in pharmacokinetic genes are associated with outcome in RA patients receiving MTX. Patients & methods: We analyzed 28 SNPs in SLC19A1/RFC1, ABCB1, FPGS and GGH genes. Results: We studied 194 RA patients receiving MTX monotherapy. Two FPGS SNPs, rs10987742 and rs10106, were associated with response (p = 0.033 and p = 0.041, respectively). The FPGS rs10106 variant was also associated with MTX survival (p = 0.005) and toxicity (p = 0.021). Three ABCB1 SNPs, rs868755, rs10280623 and rs1858923, were associated with toxicity (p = 0.025, p = 0.048 and p = 0.031, respectively). Conclusion: FPGS and ABCB1 genetic variants can influence the outcome in RA patients receiving MTX monotherapy.

AB - © 2016 Future Medicine Ltd. Background: Methotrexate (MTX) is the most used drug for the treatment of rheumatoid arthritis (RA) although outcome differs among patients. Aim: To evaluate whether polymorphisms in pharmacokinetic genes are associated with outcome in RA patients receiving MTX. Patients & methods: We analyzed 28 SNPs in SLC19A1/RFC1, ABCB1, FPGS and GGH genes. Results: We studied 194 RA patients receiving MTX monotherapy. Two FPGS SNPs, rs10987742 and rs10106, were associated with response (p = 0.033 and p = 0.041, respectively). The FPGS rs10106 variant was also associated with MTX survival (p = 0.005) and toxicity (p = 0.021). Three ABCB1 SNPs, rs868755, rs10280623 and rs1858923, were associated with toxicity (p = 0.025, p = 0.048 and p = 0.031, respectively). Conclusion: FPGS and ABCB1 genetic variants can influence the outcome in RA patients receiving MTX monotherapy.

KW - ABCB1

KW - FPGS

KW - GGH

KW - methotrexate

KW - pharmacogenetics

KW - rheumatoid arthritis

KW - SLC19A1/RFC1

U2 - 10.2217/pgs.15.150

DO - 10.2217/pgs.15.150

M3 - Article

SP - 11

EP - 25

JO - Pharmacogenomics

JF - Pharmacogenomics

SN - 1462-2416

IS - 1

ER -