Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events

David Ramos-Vicente, Jie Ji, Esther Gratacòs-Batlle, Gemma Gou, Rita Reig-Viader, Javier Luís, Demian Burguera, Enrique Navas-Perez, Jordi García-Fernández, Pablo Fuentes-Prior, Hector Escriva, Nerea Roher, David Soto, Àlex Bayés

Research output: Contribution to journalArticleResearch

19 Citations (Scopus)

Abstract

© Ramos-Vicente et al. Glutamate receptors are divided in two unrelated families: ionotropic (iGluR), driving synaptic transmission, and metabotropic (mGluR), which modulate synaptic strength. The present classification of GluRs is based on vertebrate proteins and has remained unchanged for over two decades. Here we report an exhaustive phylogenetic study of GluRs in metazoans. Importantly, we demonstrate that GluRs have followed different evolutionary histories in separated animal lineages. Our analysis reveals that the present organization of iGluRs into six classes does not capture the full complexity of their evolution. Instead, we propose an organization into four subfamilies and ten classes, four of which have never been previously described. Furthermore, we report a sister class to mGluR classes I-III, class IV. We show that many unreported proteins are expressed in the nervous system, and that new Epsilon receptors form functional ligand-gated ion channels. We propose an updated classification of glutamate receptors that includes our findings.
Original languageEnglish
Article numbere35774
Pages (from-to)-
JournaleLife
Volume22
Issue number7
DOIs
Publication statusPublished - 1 Nov 2018

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