Metal-saccharide chemistry and biology: Saccharide complexes of zinc and their effect on metallothionein synthesis in mice

Rajiv P. Bandwar; Mercedes Giralt; Juan Hidalgo; Chebrolu P. Rao

doi:https://doi.org/10.1016/0008-6215(96)00009-2

Metal-saccharide chemistry and biology: Saccharide complexes of zinc and their effect on metallothionein synthesis in mice

Rajiv P. Bandwar, Mercedes Giralt, Juan Hidalgo, Chebrolu P. Rao

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36 Citations (Scopus)

Abstract

Monosaccharide (D-Fru, D-Gal, D-Glc, D-Xyl, and D-Rib) and disaccharide (Mal) complexes of Zn2+ were synthesised using different precursors and isolated in the solid state. These were found to be anionic with a Zn-to-saccharide ratio of 1:1 and 2:1 for monosaccharide and disaccharide complexes, respectively. Electrochemical behaviour in aqueous solution was studied by extensive cyclic voltammetric studies in the pH range 3.7-10.3. The effect of subcutaneously injected Zn-D-Fru, Zn-D-Gal and Zn-D-Glc complexes on the metallothionein synthesis in mice was found to be significant in the liver, but not in the brain.

Original language	English
Pages (from-to)	73-84
Journal	Carbohydrate Research
Volume	284
DOIs	https://doi.org/10.1016/0008-6215(96)00009-2
Publication status	Published - 18 Apr 1996

Keywords

complex, metal-saccharide
metallothionein
zinc-saccharide complex

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https://doi.org/10.1016/0008-6215(96)00009-2

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title = "Metal-saccharide chemistry and biology: Saccharide complexes of zinc and their effect on metallothionein synthesis in mice",

abstract = "Monosaccharide (D-Fru, D-Gal, D-Glc, D-Xyl, and D-Rib) and disaccharide (Mal) complexes of Zn2+ were synthesised using different precursors and isolated in the solid state. These were found to be anionic with a Zn-to-saccharide ratio of 1:1 and 2:1 for monosaccharide and disaccharide complexes, respectively. Electrochemical behaviour in aqueous solution was studied by extensive cyclic voltammetric studies in the pH range 3.7-10.3. The effect of subcutaneously injected Zn-D-Fru, Zn-D-Gal and Zn-D-Glc complexes on the metallothionein synthesis in mice was found to be significant in the liver, but not in the brain.",

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TY - JOUR

T1 - Metal-saccharide chemistry and biology: Saccharide complexes of zinc and their effect on metallothionein synthesis in mice

AU - Bandwar, Rajiv P.

AU - Giralt, Mercedes

AU - Hidalgo, Juan

AU - Rao, Chebrolu P.

PY - 1996/4/18

Y1 - 1996/4/18

N2 - Monosaccharide (D-Fru, D-Gal, D-Glc, D-Xyl, and D-Rib) and disaccharide (Mal) complexes of Zn2+ were synthesised using different precursors and isolated in the solid state. These were found to be anionic with a Zn-to-saccharide ratio of 1:1 and 2:1 for monosaccharide and disaccharide complexes, respectively. Electrochemical behaviour in aqueous solution was studied by extensive cyclic voltammetric studies in the pH range 3.7-10.3. The effect of subcutaneously injected Zn-D-Fru, Zn-D-Gal and Zn-D-Glc complexes on the metallothionein synthesis in mice was found to be significant in the liver, but not in the brain.

AB - Monosaccharide (D-Fru, D-Gal, D-Glc, D-Xyl, and D-Rib) and disaccharide (Mal) complexes of Zn2+ were synthesised using different precursors and isolated in the solid state. These were found to be anionic with a Zn-to-saccharide ratio of 1:1 and 2:1 for monosaccharide and disaccharide complexes, respectively. Electrochemical behaviour in aqueous solution was studied by extensive cyclic voltammetric studies in the pH range 3.7-10.3. The effect of subcutaneously injected Zn-D-Fru, Zn-D-Gal and Zn-D-Glc complexes on the metallothionein synthesis in mice was found to be significant in the liver, but not in the brain.

KW - complex, metal-saccharide

KW - metallothionein

KW - zinc-saccharide complex

U2 - https://doi.org/10.1016/0008-6215(96)00009-2

DO - https://doi.org/10.1016/0008-6215(96)00009-2

M3 - Article

SN - 0008-6215

VL - 284

SP - 73

EP - 84

JO - Carbohydrate Research

JF - Carbohydrate Research

ER -

Metal-saccharide chemistry and biology: Saccharide complexes of zinc and their effect on metallothionein synthesis in mice

Abstract

Keywords

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