Metal-mediated deamination of cytosine: Experiment and DFT calculations

Judit E. Šponer, Pablo J. Sanz Miguel, Luis Rodríguez-Santiago, Andrea Erxleben, Michael Krumm, Mariona Sodupe, Jirí Šponer, Bernhard Lippert

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28 Citations (Scopus)

Abstract

A mechanism goes platinum: Hydrolytic deamination of cytosine is a major mutagenic event in DNA. Studies with a model system and DFT calculcations demonstrate that deamination is facilitated by coordination of the Pt II center to the N3 atom (see scheme; C = cytosine, U = uracil).
Original languageEnglish
Pages (from-to)5396-5399
JournalAngewandte Chemie - International Edition
Volume43
Issue number40
DOIs
Publication statusPublished - 11 Oct 2004

Keywords

  • Cytosine
  • Deamination
  • Density functional calculations
  • Nucleobases
  • Platinum

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