Metabostemness: Metaboloepigenetic reprogramming of cancer stem-cell functions

Javier A. Menendez, Bruna Corominas-Faja, Elisabet Cuyàs, Tomás Alarcón

    Research output: Contribution to journalArticleResearchpeer-review

    26 Citations (Scopus)

    Abstract

    Cancer researchers are currently embarking on one of their field's biggest challenges, namely the understanding of how cellular metabolism or certain classes of elite metabolites (e.g., oncometabolites) can directly influence chromatin structure and the functioning of epi-transcriptional circuits to causally drive tumour formation. We here propose that refining the inherent cell attractor nature of nuclear reprogramming phenomena by adding the under-appreciated capacity of metabolism to naturally reshape the Waddingtonian landscape's topography provides a new integrative metabolo-epigenetic model of the cancer stem cell (CSC) theory.
    Original languageEnglish
    Pages (from-to)803-806
    JournalOncoscience
    Volume1
    Issue number12
    DOIs
    Publication statusPublished - 1 Jan 2014

    Keywords

    • Cancer
    • Cancer stem cells
    • Oncometabolites
    • Reprogramming
    • Stem cells
    • Stemness

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