Metabostemness: Metaboloepigenetic reprogramming of cancer stem-cell functions

Javier A. Menendez, Bruna Corominas-Faja, Elisabet Cuyàs, Tomás Alarcón

    Research output: Contribution to journalArticleResearchpeer-review

    27 Citations (Scopus)


    Cancer researchers are currently embarking on one of their field's biggest challenges, namely the understanding of how cellular metabolism or certain classes of elite metabolites (e.g., oncometabolites) can directly influence chromatin structure and the functioning of epi-transcriptional circuits to causally drive tumour formation. We here propose that refining the inherent cell attractor nature of nuclear reprogramming phenomena by adding the under-appreciated capacity of metabolism to naturally reshape the Waddingtonian landscape's topography provides a new integrative metabolo-epigenetic model of the cancer stem cell (CSC) theory.
    Original languageEnglish
    Pages (from-to)803-806
    Issue number12
    Publication statusPublished - 1 Jan 2014


    • Cancer
    • Cancer stem cells
    • Oncometabolites
    • Reprogramming
    • Stem cells
    • Stemness


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