Metabolism of exogenous arachidonic acid by polymorphonuclear leukocytes from psoriatic patients

J. Solá, L. Vila, L. Puig, J. M. de Moragas

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8 Citations (Scopus)

Abstract

We evaluated the metabolism of exogenous arachidonic acid in polymorphonuclear leukocytes from psoriatic patients in comparison with those from normal subjects. The leukocytes were incubated with 10 ΜM labelled arachidonic acid and 5 ΜM A23187 for varying periods of time. We evaluated all the compounds derived from the 5-lipoxygenase activity, including the products of non-enzymatic transformation of leukotriene A4 and w-oxidized leukotriene B4. In the experimental conditions used, there was no significant difference in the formation of any compound at any time of incubation. These results indicate that there is no intrinsic alteration either in 5-lipoxygenase activity or in w-oxidation ability of circulating polymorphonuclear leukocytes in psoriatic patients. © 1991 Springer-Verlag.
Original languageEnglish
Pages (from-to)77-80
JournalArchives of Dermatological Research
Volume283
Issue number2
DOIs
Publication statusPublished - 1 Apr 1991

Keywords

  • Arachidonic acid
  • Eicosanoids
  • Polymorphonuclear leukocytes
  • Psoriasis

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