Metabolic syndrome, type 1 diabetes mellitus and insulin resistance

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Abstract

Although metabolic syndrome is generally associated with type 2 diabetes mellitus, the present review emphasizes the possible presence of metabolic syndrome in type 1 diabetes and the impact of insulin resistance on micro- and macrovascular complications. Results of major intervention studies in type 1 diabetes have led to a generalized intensive insulin treatment, being an excessive weight gain one of the consequences. Since abdominal obesity and hyperglycemia are 2 components of the metabolic syndrome, an increase in the percentage of metabolic syndrome in patients with type 1 diabetes is not surprising, though its prevalence does not reach that reported for type 2 diabetes. For insulin sensitivity quantification in patients with type 1 diabetes the estimated glucose disposal rate (eGDR): it consists of calculating a score based on clinical factors of the patient, which shows an inverse relationship with the development of micro- and macrovascular complications. Moreover, insulin-resistance identification in type 1 diabetes may have therapeutic implications.
Original languageEnglish
Pages (from-to)466-471
JournalMedicina Clinica
Volume130
Issue number12
DOIs
Publication statusPublished - 5 Apr 2008

Keywords

  • Cardiovascular disease
  • Glycemic control
  • Hyperinsulinemia
  • Insulin-resistance
  • Metabolic syndrome
  • Type 1 diabetes

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