Metabolic syndrome in children and adolescents living with HIV

María Espiau, Diego Yeste, Antoni Noguera-Julian, María I. González-Tomé, Lola Falcón-Neyra, César Gavilán, María L. Navarro-Gómez, María J. Mellado-Peña, Mercedes Gracia-Casanova, María E. Colino-Gil, Maria Méndez, Luis M. Ciria Calavia, Clàudia Fortuny, Antonio Carrascosa, Pere Soler-Palacín, Concepció Figueras, Andrea Martín-Nalda, Marta Dapena, Carmen López, Olga CalaviaLuis Mayol Canals, Neus Rius, Lourdes García Rodríguez, Antonio Mur

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Abstract

copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. Background: Metabolic syndrome (MetS) is considered an independent risk factor for developing cardiovascular disease. It is well known that the prevalence of metabolic disorders have increased in pediatric HIV-infected children. The objective of this study is to assess the prevalence and characteristics of MetS in HIV-infected children and adolescents in Spain. Methods: A cross-sectional multicenter study in 152 patients from the pediatric cohort of the Spanish AIDS Research Network (CoRISpe) was performed. MetS was defined according to the new International Diabetes Federation (IDF) diagnostic criteria and the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria. Measurements included anthropometry, waist circumference, blood pressure, fasting lipids, glucose and insulin and lipodystrophy assessment. Demographic, clinical, immunological, virological and antiretroviral therapy data were obtained from the Network database. Results: An abnormally low high-density lipoprotein-cholesterol level was the most prevalent disturbance (21.05%) found. Three patients met IDF criteria for MetS (1.97%), and MetS was significantly associated with lipohypertrophy (P=0.029) in the analysis. When the modified NCEP-ATP III criteria were used, the prevalence of MetS was 5.92% (9 patients), and MetS was significantly associated with Tanner stage ≥2 (P=0.041), lipohypertrophy (P=0.001) and higher Z scores for weight and body mass index (P=0.002 and P<0.001). Insulin resistance was observed in 17 patients (11.18%) and was associated with MetS (as per the modified NCEP-ATP III criteria) (P=0.03) and lower high-density lipoprotein-cholesterol values (P=0.036). Conclusions: The prevalence of MetS in our cohort was 1.97% or 5.92%, depending on the diagnostic criteria used. MetS should be actively assessed, particularly in children who show lipohypertrophy.
Original languageEnglish
Pages (from-to)e171-e176
JournalPediatric Infectious Disease Journal
Volume35
Issue number6
DOIs
Publication statusPublished - 1 Jan 2016

Keywords

  • Antiretroviral therapy
  • HIV
  • Insulin resistance
  • Metabolic syndrome
  • Standards

Fingerprint Dive into the research topics of 'Metabolic syndrome in children and adolescents living with HIV'. Together they form a unique fingerprint.

  • Cite this

    Espiau, M., Yeste, D., Noguera-Julian, A., González-Tomé, M. I., Falcón-Neyra, L., Gavilán, C., Navarro-Gómez, M. L., Mellado-Peña, M. J., Gracia-Casanova, M., Colino-Gil, M. E., Méndez, M., Ciria Calavia, L. M., Fortuny, C., Carrascosa, A., Soler-Palacín, P., Figueras, C., Martín-Nalda, A., Dapena, M., López, C., ... Mur, A. (2016). Metabolic syndrome in children and adolescents living with HIV. Pediatric Infectious Disease Journal, 35(6), e171-e176. https://doi.org/10.1097/INF.0000000000001118