Metabolic Syndrome and Type-1 Diabetes Mellitus: Prevalence and Associated Factors

Juan J. Chillarón, Juana A. Flores-Le-Roux, Alberto Goday, David Benaiges, María J. Carrera, Jaume Puig, Juan F. Cano-Pérez, Juan Pedro-Botet

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29 Citations (Scopus)


Introduction and objectives: Numerous clinical and epidemiological studies have highlighted the fact that metabolic syndrome is an important precursor of cardiovascular disease. Metabolic syndrome is generally associated with type-2 diabetes, and few data exist on its occurrence in type-1 diabetes. The aims of this study were to determine the prevalence of metabolic syndrome in patients with type-1 diabetes and to identify associated factors. Methods: This cross-sectional study included consecutive patients aged over 18 years with autoimmune type-1 diabetes of more than 6 months' duration who were treated during 2008 at the Outpatient Endocrinology Clinic of the Hospital del Mar, Barcelona, Spain. The presence of metabolic syndrome was determined using the modified criteria proposed by the National Cholesterol Education Program-Adult Treatment Panel III. Results: Overall, 31.9% (95% confidence interval [CI], 22.3%-41.5%) of patients with type-1 diabetes had metabolic syndrome. The following factors were significantly and independently associated with the presence of metabolic syndrome in patients with type-1 diabetes: age (odds ratio [OR]=1.09; 95% CI, 1.029-1.154), body mass index (OR=1.389; 95% CI, 1.134-1.702) and glycosylated hemoglobin level (OR=1.745; 95% CI, 1.081-2.815). In addition, there was a direct relationship between the number of components of metabolic syndrome present and prevalence of microangiopathy, which reached 100% in patients who satisfied all diagnostic criteria. Conclusions: Metabolic syndrome was common in patients with type-1 diabetes and was associated with microvascular complications. © 2010 Sociedad Española de Cardiología.
Original languageEnglish
Pages (from-to)423-429
JournalRevista Espanola de Cardiologia
Issue number4
Publication statusPublished - 1 Apr 2010


  • Diabetes mellitus
  • Insulin resistance
  • Metabolic syndrome
  • Microvascular complications

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