Metabolic effects of chronic ACTH administration, interaction with response to stress

A. Armario, L. Campmany, J. Hidalgo

    Research output: Contribution to journalArticleResearchpeer-review

    4 Citations (Scopus)

    Abstract

    The present experiment was undertaken to study the metabolic response to stress of single or chronic ACTH-treated male rats. It was found that chronic ACTH-treated rats showed a slight reduction in food intake and a decrease in body weight gain. This treatment increased basal serum triglyceride and insulin levels. In addition, some differences in response to stress was found in chronic ACTH-treated rats. Thus, these latter animals, unlike the other two groups, showed a decrease in circulating triglyceride and insulin levels in response to short-term stress. Moreover, 24 h after onset of stress a more marked fall in liver weight and glucose levels were found in chronic ACTH-treated rats. It suggests that chronic ACTH treatment might alter the metabolic response to prolonged acute stress what could result in lower resistance to severe stresses. © 1986 S. Karger AG, Basel.
    Original languageEnglish
    Pages (from-to)235-240
    JournalPharmacology
    Volume33
    DOIs
    Publication statusPublished - 1 Jan 1986

    Keywords

    • ACTH treatment
    • Free fatty acids
    • Glucose
    • Insulin
    • Stress
    • Triglyceride

    Fingerprint Dive into the research topics of 'Metabolic effects of chronic ACTH administration, interaction with response to stress'. Together they form a unique fingerprint.

  • Cite this