Metabolic, affective and neurocognitive characterization of metabolic syndrome patients with and without food addiction. Implications for weight progression

Lucía Camacho-Barcia, Lucero Munguía, Ignacio Lucas, Rafael de la Torre, Jordi Salas-Salvadó, Xavier Pintó, Dolores Corella, Roser Granero, Susana Jiménez-Murcia, Inmaculada González-Monje, Virginia Esteve-Luque, Aida Cuenca-Royo, Carlos Gómez-Martínez, Indira Paz-Graniel, Laura Forcano, Fernando Fernández-Aranda*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

Abstract

According to the food addiction (FA) model, the consumption of certain types of food could be potentially addictive and can lead to changes in intake regulation. We aimed to describe metabolic parameters, dietary characteristics, and affective and neurocognitive vulnerabilities of individuals with and without FA, and to explore its influences on weight loss progression. The sample included 448 adults (55–75 years) with overweight/obesity and metabolic syndrome from the PREDIMED-Plus cognition sub-study. Cognitive and psychopathological assessments, as well as dietary, biochemical, and metabolic measurements, were assessed at baseline. Weight progression was evaluated after a 3-year follow up. The presence of FA was associated with higher depressive symptomatology, neurocognitive decline, low quality of life, high body mass index (BMI), and high waist circumference, but not with metabolic comorbidities. No differences were observed in the dietary characteristics except for the saturated and monounsaturated fatty acids consumption. After three years, the presence of FA at baseline resulted in a significantly higher weight regain. FA is associated with worse psychological and neurocognitive state and higher weight regain in adults with metabolic syndrome. This condition could be an indicator of bad prognosis in the search for a successful weight loss process.

Original languageEnglish
Article number2779
JournalNutrients
Volume13
Issue number8
DOIs
Publication statusPublished - Aug 2021

Keywords

  • Depression
  • Food addiction
  • Metabolic syndrome
  • Neurocognitive state
  • Quality of life

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