Meningeal carcinomatosis as the first manifestation of a transitional cell carcinoma of the bladder

Jordi Bruna Escuer, Íñigo Rojas-Marcos, Sergio Martínez-Yelamos, Isabel Català, Antonio Villader, Carmen Galán, Jurek Krupinski, Francisco Rubio

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21 Citations (Scopus)

Abstract

Meningeal carcinomatosis (MC) as first manifestation of a transitional cell carcinoma (TCC) of the bladder is rare. We report a 66-year-old man, smoker, who presented with two episodes of secondarily generalized partial motor seizures. The routine blood test, brain computed tomography (CT) scan, brain magnetic resonance imaging and electroencephalogram were normal. Cerebral spinal fluid (CSF) revealed a significant pleocytosis and a morphology compatible with non-differentiated non-small cell carcinoma. Broncofiberscopy, gastrofiberscopy, thoracicoabdominopelvic CT-scan and bone scintigraphy were normal but the urine cytology revealed malignant cells similar to those found in the CSF. TCC was diagnosed by cystoscopy and later necropsy confirmed the MC of this tumor. In this report we review the literature and analyze patient survival.
Original languageEnglish
Pages (from-to)63-67
JournalJournal of Neuro-Oncology
Volume63
Issue number1
DOIs
Publication statusPublished - 1 May 2003

Keywords

  • Bladder tumor
  • CSF cytology
  • Meningeal carcinomatosis
  • Seizures
  • Transitional cell carcinoma
  • Urine cytology

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