Medical-grade silicone induces release of proinflammatory cytokines in peripheral blood mononuclear cells without activating T cells

Francesc Miro-Mur, Mathilde Hindié, Renuka Kandhaya-Pillai, Vanessa Tobajas, Simo Schwartz, Jaume Alijotas-Reig

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21 Citations (Scopus)


For more than 40 years, silicone implants had been employed in aesthetic, cosmetic medicine, and plastic surgery. Although adverse reactions produced by these products are rare, cases of immuno-mediated reactions have been reported. To evaluate the aspects of immuno-reactivity to medical-grade silicone dermal filler, peripheral blood mononuclear cells (PBMC) of 39 individuals were studied. PBMC used include individuals with silicone injectionrelated delayed adverse reactions, with silicone injections, and healthy control. Silicone induced production of TNF-α and IL-6 in all three groups. Notably, elevated production of IL-6 was observed in nonstimulated PBMC and also the percentage of CD4+CD69+ T cells was higher in PHA-stimulated PBMC from individuals with silicone injection-related adverse reactions when compared with other two groups. However, IFN-γ was not released in siliconestimulated or silicone+ LPS-stimulated PBMC from any group and no production of IL-2 was measured indicating no proliferative response of PBMC. Subsequently, no CD4+CD69+ T cells were observed in these conditions. Finally, the inflammatory response in siliconestimulated cultures of monocyte-derived macrophages with autologous lymphocytes is lesser than that observed in PBMC. In conclusion, silicone induces a release of proinflammatory cytokines but does not act as a polyclonal activator of CD4 + T cells. Thus, silicone is mounting an immune response in individuals with silicone-related adverse effects but is not silicone antigen-dependent. © 2009 Wiley Periodicals, Inc.
Original languageEnglish
Pages (from-to)510-520
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume90 B
Issue number2
Publication statusPublished - 1 Jan 2009


  • Inflammation
  • Late adverse reactions
  • PBMC
  • Silicone dermal filler

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