Mechanisms of genetically-based resistance to malaria

Carolina López, Carolina Saravia, Andromeda Gomez, Johan Hoebeke, Manuel A. Patarroyo*

*Corresponding author for this work

Research output: Contribution to journalReview articleResearchpeer-review

86 Citations (Scopus)

Abstract

Malaria remains one of the most prevalent parasitoses worldwide. About 350 to 500. million febrile episodes are observed yearly in African children alone and more than 1. million people die because of malaria each year. Multiple factors have hampered the effective control of this disease, some of which include the complex biology of the Plasmodium parasites, their high polymorphism and their increasingly high resistance to antimalarial drugs, mainly in endemic regions. The ancient interaction between malarial parasites and humans has led to the fixation in the population of several inherited alterations conferring protection against malaria. Some of the mechanisms underlying protection against this disease are described in this review for hemoglobin-inherited disorders (thalassemia, sickle-cell trait, HbC and HbE), erythrocyte polymorphisms (ovalocytosis and Duffy blood group), enzymopathies (G6PD deficiency and PK deficiency) and immunogenetic variants (HLA alleles, complement receptor 1, NOS2, tumor necrosis factor-Α promoter and chromosome 5q31-q33 polymorphisms).

Original languageAmerican English
Pages (from-to)1-12
Number of pages12
JournalGene
Volume467
Issue number1-2
DOIs
Publication statusPublished - Nov 2010

Keywords

  • Erythrocyte polymorphism
  • Hemoglobinopathy
  • Malaria
  • Natural resistance

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