Mecanismos básicos: Estructura, función y metabolismo de las lipoproteínas plasm

Teresa L. Errico, Xiangyu Chen, Jesús M. Martin Campos, Josep Julve, Joan Carles Escolà-Gil, Francisco Blanco-Vaca

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

The aim of this work is to present basic information on the lipoprotein physiology. The protein fraction of lipoproteins consists of several apolipoproteins and enzymes whose functions are lipid transport and metabolism. Classification of lipoproteins is based on their density. Chylomicrons, VLDL, IDL, LDL and HDL can be isolated by ultracentrifugation. Both chylomicrons- and VLDL-triglycerides are transported from the intestine and liver, respectively, to the peripheral tissues. The metabolism of VLDL originates IDL and LDL. LDL is the main transporter of cholesterol to extrahepatic tissues. HDL mobilizes cholesterol from peripheral tissues to the liver where it is secreted to bile as free cholesterol or bile salts, a process termed reverse cholesterol transport. Lipoprotein metabolism can be regulated by nuclear receptors that regulate the expression of genes involved in triglyceride and apolipoprotein metabolism. © 2013 Elsevier España, S.L. y SEA.
Original languageEnglish
Pages (from-to)98-103
JournalClinica e Investigacion en Arteriosclerosis
Volume25
Issue number2
DOIs
Publication statusPublished - 1 Apr 2013

Keywords

  • Apolipoprotein
  • Cholesterol
  • Lipoprotein
  • Triglyceride

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