Measurement of motor disability in MPTP-treated macaques using a telemetry system for estimating circadian motor activity

C. Barcia*, V. De Pablos, V. Bautista-Hernández, A. Sanchez-Bahillo, A. Fernández-Barreiro, M. Poza, M. T. Herrero

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

The parkinsonian symptoms of primates after MPTP exposure can be measured by several visual methods (classical motor scores). However, these methods have a subjective bias, especially as regards the evaluation of the motor activity. Computerized monitoring systems represent an unbiased method for measuring the motor disability of monkeys after MPTP administration. In this work the motor activity of monkeys before and after MPTP administration is measured and compared with the activity of a control intact group by means of a telemetry system. A pronounced decrease in motor activity was observed after MPTP administration. These results suggest the monitoring method used is suited for characterizing the motor incapacity and possible improvements following treatments to test different therapies to control Parkinson's disease in MPTP models involving primates.

Original languageEnglish
Pages (from-to)59-64
Number of pages6
JournalJournal of Neuroscience Methods
Volume134
Issue number1
DOIs
Publication statusPublished - 15 Mar 2004

Keywords

  • Circadian rhythms
  • Macaques
  • Motor activity
  • MPTP
  • Parkinsonian syndrome

Fingerprint

Dive into the research topics of 'Measurement of motor disability in MPTP-treated macaques using a telemetry system for estimating circadian motor activity'. Together they form a unique fingerprint.

Cite this